Augustin Hrvoje, Adcott Jennifer, Elliott Christopher J H, Partridge Linda
a Institute of Healthy Ageing, and the Department of Genetics, Evolution, and Environment , University College London , Darwin Building, Gower Street, London , UK.
b Max Planck Institute for Biology of Ageing , Cologne , Germany.
Fly (Austin). 2017 Oct 2;11(4):284-289. doi: 10.1080/19336934.2017.1369638. Epub 2017 Aug 24.
Myoglianin, the Drosophila homolog of the secreted vertebrate proteins Myostatin and GDF-11, is an important regulator of neuronal modeling, and synapse function and morphology. While Myoglianin suppression during development elicits positive effects on the neuromuscular system, genetic manipulations of myoglianin expression levels have a varied effect on the outcome of performance tests in aging flies. Specifically, Myoglianin preserves jumping ability, has no effect on negative geotaxis, and negatively regulates flight performance in aging flies. In addition, Myoglianin exhibits a tissue-specific effect on longevity, with myoglianin upregulation in glial cells increasing the median lifespan. These findings indicate complex role for this TGF-β-like protein in governing neuromuscular signaling and consequent behavioral outputs and lifespan in adult flies.
肌动蛋白，是脊椎动物分泌蛋白肌生成抑制素和生长分化因子11在果蝇中的同源物，是神经元建模、突触功能和形态的重要调节因子。虽然在发育过程中抑制肌动蛋白对神经肌肉系统有积极影响，但肌动蛋白表达水平的基因操作对衰老果蝇的性能测试结果有不同影响。具体而言，肌动蛋白可维持跳跃能力，对负趋地性无影响，并对衰老果蝇的飞行性能有负调节作用。此外，肌动蛋白对寿命表现出组织特异性影响，胶质细胞中肌动蛋白的上调可延长平均寿命。这些发现表明，这种类转化生长因子β蛋白在控制成年果蝇的神经肌肉信号传导以及由此产生的行为输出和寿命方面具有复杂作用。
