Department of Genetics, Cell Biology and Development University of Minnesota, Minneapolis, United States.
Elife. 2020 Jul 7;9:e51710. doi: 10.7554/eLife.51710.
Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.
组织的生长和大小是由内在和外在信号分子精细调节的。在 BMP 家族成员 Dpp 中，它在一组有限的成虫盘细胞中产生，并作为一种经典的形态发生素，通过在成虫盘中扩散来调节模式和生长。然而，TGFβ/Activin 样配体在盘生长控制中的作用仍不清楚。在这里，我们证明了 Myoglianin（Myo），一种 Activin 家族成员，也是哺乳动物 Myostatin（Mstn）的密切同源物，是一种来自肌肉的外在因子，它利用典型的 dSmad2 介导的信号转导来调节翅膀的大小。我们提出 Myo 是一种肌肉因子，有助于介导肌肉与其相关附肢之间的异速生长关系。
