Lv Zongyou, Zhang Lei, Tang Kexuan
a Joint International Research Laboratory of Metabolic & Developmental Sciences, Key Laboratory of Urban Agriculture (South) Ministry of Agriculture, Plant Biotechnology Research Center, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center , Shanghai Jiao Tong University , Shanghai , China.
b Department of Pharmaceutical Botany, School of Pharmacy , Second Military Medical University , Shanghai , China.
Plant Signal Behav. 2017 Oct 3;12(10):e1366398. doi: 10.1080/15592324.2017.1366398. Epub 2017 Aug 24.
Artemisinin is a sesquiterpene lactone coming from the traditional Chinese herb Artemisia annua L. Artemisinin combination therapies (ACTs) are the main recommended treatment of malaria. Transcription factors regulation of artemisinin belong to different families including AP2/ERF, bHLH, MYB and WRKY. Plant hormones jasmonic acid (JA), abscisic acid (ABA), salicylic acid (SA) and gibberellins (GA) have been described as positively affecting artemisinin biosynthesis in A. annua. Transporter and miRNA open up new possibilities for the biosynthesis of high value artemisinin. We review recently major developments regarding regulator which play a center role in artemisinin biosynthesis, and provide suggestion for further studies.
青蒿素是一种源自传统中草药黄花蒿的倍半萜内酯。青蒿素联合疗法（ACTs）是疟疾的主要推荐治疗方法。青蒿素的转录因子调控属于不同家族，包括AP2/ERF、bHLH、MYB和WRKY。植物激素茉莉酸（JA）、脱落酸（ABA）、水杨酸（SA）和赤霉素（GA）已被描述为对黄花蒿中青蒿素的生物合成有积极影响。转运体和微小RNA为高价值青蒿素的生物合成开辟了新的可能性。我们综述了最近在青蒿素生物合成中起核心作用的调节因子的主要进展，并为进一步研究提供建议。
