School of Food Science and Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China.
School of Food Science and Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China; School of Biological and Medical Engineering, Hefei University of Technology, Hefei 230009, People's Republic of China.
Int J Biol Macromol. 2018 Jan;106:988-993. doi: 10.1016/j.ijbiomac.2017.08.101. Epub 2017 Aug 31.
In this work, we investigated the effect of Chinese chive polysaccharides (CCP) on renal function in mice with adenine-induced chronic renal failure (CRF). Results exhibited that adenine treatment caused serious renal pathological damages and elevation of serum creatinine and blood urea nitrogen of mice. However, these changes could be significantly reversed by the administration of CCP in a dose-dependent manner. When CCP dosage reached 200mg/kg/day, the area of renal pathological damage was decreased by 59.2%, and the levels of serum creatinine and blood urea nitrogen were decreased by 23.9% and 34.7% compared to those of model group. Moreover, it was found that renal oxidative damage, inflammation and fibrosis of adenine-induced CRF mice could also be significantly inhibited by CCP. These results suggested that CCP could improve the kidney functions of adenine-induced CRF mice and the renoprotective effect might be associated with its antioxidant, anti-inflammatory and anti-fibrosis activities.
在这项工作中，我们研究了韭菜多糖（CCP）对腺嘌呤诱导的慢性肾衰竭（CRF）小鼠肾功能的影响。结果表明，腺嘌呤处理导致小鼠严重的肾脏病理损伤和血清肌酐和血尿素氮升高。然而，这些变化可以通过 CCP 的剂量依赖性给药显著逆转。当 CCP 剂量达到 200mg/kg/天时，肾脏病理损伤面积减少 59.2%，与模型组相比，血清肌酐和血尿素氮水平分别降低 23.9%和 34.7%。此外，还发现 CCP 可显著抑制腺嘌呤诱导的 CRF 小鼠的肾脏氧化损伤、炎症和纤维化。这些结果表明，CCP 可以改善腺嘌呤诱导的 CRF 小鼠的肾脏功能，其肾保护作用可能与其抗氧化、抗炎和抗纤维化活性有关。
