Koch S, Stegherr A M, Mörgeli R, Kramer S, Toubekis E, Lichtner G, von Dincklage F, Spies C
Department of Anaesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.
Department of Anaesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany.
Clin Neurophysiol. 2017 Oct;128(10):2014-2021. doi: 10.1016/j.clinph.2017.07.417. Epub 2017 Aug 9.
Anaesthesia-induced dynamics in EEG are dependent on age and level of anaesthesia, but distinct characterisation in children is incomplete. Here we analyse EEG dynamics in children related to age and level of anaesthesia.
Frontal EEG recordings were obtained from 93 children (0-19years) during routine clinical anaesthesia. EEG segments were selected at four different levels of anaesthesia: emergence, light anaesthesia, deep anaesthesia, and very deep anaesthesia.
Total power differed significantly over age at deep (R=0.314; p<0.0001) and very deep anaesthesia (R=0.403; p<0.0001). Relative beta band power at light anaesthesia increased linearly with age (R=0.239; p<0.0001). Level of anaesthesia caused significant differences for relative delta band power (increasing with anaesthetic depth), for relative beta band power and for spectral edge frequency (decreasing with anaesthetic depth) for all children (p<0.0001).
EEG parameterin children were primary dependent on anaesthetic depth, where beta band power, delta band power and spectral edge frequency showed a linear relation. Age-dependency during anaesthesia procedure were only seen for single EEG parameters.
Different levels of anaesthesia can be identified by relative beta band power, relative delta band power and spectral edge frequency irrespective of the children's age.
脑电图（EEG）中麻醉诱导的动力学取决于年龄和麻醉水平，但儿童中的特征描述尚不完整。在此，我们分析与年龄和麻醉水平相关的儿童EEG动力学。
在常规临床麻醉期间，从93名儿童（0 - 19岁）获取额叶EEG记录。在四个不同麻醉水平下选择EEG片段：苏醒期、浅麻醉、深麻醉和极深麻醉。
在深麻醉（R = 0.314；p < 0.0001）和极深麻醉（R = 0.403；p < 0.0001）时，总功率随年龄有显著差异。浅麻醉时相对β频段功率随年龄呈线性增加（R = 0.239；p < 0.0001）。麻醉水平对所有儿童的相对δ频段功率（随麻醉深度增加）、相对β频段功率和频谱边缘频率（随麻醉深度降低）均造成显著差异（p < 0.0001）。
儿童的EEG参数主要取决于麻醉深度，其中β频段功率、δ频段功率和频谱边缘频率呈线性关系。麻醉过程中的年龄依赖性仅在单个EEG参数中可见。
无论儿童年龄如何，通过相对β频段功率、相对δ频段功率和频谱边缘频率可识别不同的麻醉水平。
