García J B, Venturino M C, Cresto J C, Pivetta O H, Basabe J C
Acta Physiol Pharmacol Latinoam. 1986;36(3):277-87.
Insulin and somatostatin (SRIF) secretion induced by alloantigen were studied in genetically diabetic mice from the C57BL/KsJ mdb-mdb strain. Diabetic (db) mice injected with allogeneic lymphocytes (A.L.) did not show any increase in their second phase of 27.5 mM glucose stimulated secretion and slightly increased their first phase. Normal A.L. injected mice showed a significant increase in both phases of 27.5 mM glucose stimulated secretion. SRIF secretion of A.L. injected normal and diabetic mice did not significantly differ from that obtained when injected with syngeneic lymphocytes. Lymphocytes from db mice injected into allogeneic mice caused an insulin secretion similar to that produced by allogeneic lymphocytes from non-diabetic mice. Lymphocytes from db mice injected into normal syngeneic mice caused an insulin secretion which was not significantly different from the one caused by syngeneic lymphocytes from non-diabetic mice, and is smaller than the secretion caused by A.L. injection. In summary, db mice showed an impaired hormone response to alloantigenic stimulus, while their lymphocytes maintained their alloantigenic action.
在来自C57BL/KsJ mdb - mdb品系的遗传性糖尿病小鼠中，研究了同种异体抗原诱导的胰岛素和生长抑素（SRIF）分泌。注射同种异体淋巴细胞（A.L.）的糖尿病（db）小鼠在27.5 mM葡萄糖刺激分泌的第二阶段未显示任何增加，且第一阶段略有增加。注射正常A.L.的小鼠在27.5 mM葡萄糖刺激分泌的两个阶段均显示出显著增加。注射A.L.的正常和糖尿病小鼠的SRIF分泌与注射同基因淋巴细胞时获得的分泌无显著差异。将db小鼠的淋巴细胞注射到同种异体小鼠中引起的胰岛素分泌与非糖尿病小鼠的同种异体淋巴细胞产生的胰岛素分泌相似。将db小鼠的淋巴细胞注射到正常同基因小鼠中引起的胰岛素分泌与非糖尿病小鼠的同基因淋巴细胞引起的胰岛素分泌无显著差异，且小于注射A.L.引起的分泌。总之，db小鼠对同种异体抗原刺激的激素反应受损，而其淋巴细胞保持其同种异体抗原作用。
