García J B, Venturino M C, Cresto J C, Pivetta O H, Basabe J C
Horm Metab Res. 1987 Jul;19(7):290-4. doi: 10.1055/s-2007-1011803.
Plasma from BALB/c mice bled 90 minutes after allogeneic lymphocyte injection significantly rises glucose induced insulin secretion. This rise is observed in pancreas either from non-treated or from allogeneized mice. This rise is time and dose-dependent. An 1/40 dilution is enough to bring about a significant increase on insulin secretion. This effect is seen when mice are bled between 60 and 180 minutes after injection with a maximum effect at 90-120 minutes. Plasma from BALB/c mice injected with C57BL/6 J lymphocytes rises insulin secretion from BALB/c, C57BL/6 J, C3h and C57BL/KsJ mice pancreas. Plasma from streptozotocin diabetic BALB/c mice and from genetically diabetic C57BL/KsJ mdb-mdb mice injected with allogeneic lymphocytes stimulates glucose induced insulin secretion but to a lesser extent than plasma from normal non-diabetic mice does.
在注射同种异体淋巴细胞90分钟后采集的BALB/c小鼠血浆，能显著提高葡萄糖诱导的胰岛素分泌。在未处理小鼠或同种异体化小鼠的胰腺中均观察到这种升高。这种升高具有时间和剂量依赖性。1/40的稀释度就足以使胰岛素分泌显著增加。当在注射后60至180分钟之间采集小鼠血液时可观察到这种效应，在90 - 120分钟时效果最佳。注射C57BL/6 J淋巴细胞的BALB/c小鼠血浆可提高BALB/c、C57BL/6 J、C3h和C57BL/KsJ小鼠胰腺的胰岛素分泌。注射同种异体淋巴细胞的链脲佐菌素诱导糖尿病的BALB/c小鼠和遗传性糖尿病的C57BL/KsJ mdb - mdb小鼠的血浆能刺激葡萄糖诱导的胰岛素分泌，但程度低于正常非糖尿病小鼠的血浆。
