磁共振弹性成像作为肾移植中纤维化无创测量工具的作用：一例报告
Role of Magnetic Resonance Elastography as a Noninvasive Measurement Tool of Fibrosis in a Renal Allograft: A Case Report.
作者信息
Kim J K, Yuen D A, Leung G, Jothy S, Zaltzman J, Ramesh Prasad G V, Prabhudesai V, Mnatzakanian G, Kirpalani A
机构信息
Department of Medical Imaging, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada; Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
Keenan Research Centre of the Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of Nephrology, Department of Medicine, St. Michael's Hospital and University of Toronto, Toronto, Ontario, Canada.
出版信息
Transplant Proc. 2017 Sep;49(7):1555-1559. doi: 10.1016/j.transproceed.2017.04.002.
A major reason for poor long-term kidney transplant outcomes is the development of chronic allograft injury, characterized by interstitial fibrosis and tubular atrophy. Currently, an invasive biopsy that samples only <1% of the kidney is the gold standard for detecting kidney allograft fibrosis. We report the use of magnetic resonance elastography (MRE) to quantify tissue stiffness as a noninvasive and whole-kidney measurement tool of allograft fibrosis in a kidney transplant patient at 2 time points. The MRE whole-kidney stiffness values reflected the changes in fibrosis of the kidney allograft as assessed by histologic examination. To our knowledge, this technique is the first observation of change over time in MRE-derived whole-kidney stiffness in an allograft that is consistent with changes in histology-derived fibrosis scores in a single patient.
长期肾移植预后不佳的一个主要原因是慢性移植肾损伤的发生，其特征为间质纤维化和肾小管萎缩。目前，仅对不到1%的肾脏进行采样的侵入性活检是检测移植肾纤维化的金标准。我们报告了在一名肾移植患者的两个时间点使用磁共振弹性成像（MRE）来量化组织硬度，作为一种无创的全肾移植肾纤维化测量工具。MRE全肾硬度值反映了通过组织学检查评估的移植肾纤维化变化。据我们所知，这项技术首次观察到在同一名患者中，移植肾MRE衍生的全肾硬度随时间的变化与组织学衍生的纤维化评分变化一致。
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