Munk Rachel, Panda Amaresh C, Grammatikakis Ioannis, Gorospe Myriam, Abdelmohsen Kotb
Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Laboratory of Genetics and Genomics, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Int Rev Cell Mol Biol. 2017;334:177-205. doi: 10.1016/bs.ircmb.2017.03.008. Epub 2017 Apr 28.
Senescent cells arise as a consequence of cellular damage and can have either a detrimental or advantageous impact on tissues and organs depending on the specific cell type and metabolic state. As senescent cells accumulate in tissues with advancing age, they have been implicated in many age-related declines and diseases. The major facets of senescence include two pathways responsible for establishing and maintaining a senescence program, p53/CDKN1A(p21) and CDKN2A(p16)/RB, as well as the senescence-associated secretory phenotype. Numerous MicroRNAs influence senescence by modulating the abundance of key senescence regulatory proteins, generally by lowering the stability and/or translation of mRNAs that encode such factors. Accordingly, understanding the molecular mechanisms by which MicroRNAs influence senescence will enable diagnostic and therapeutic opportunities directed at senescent cells. Here, we review senescence-associated (SA)-MicroRNAs and discuss their implications in senescence-relevant pathologies.
衰老细胞是细胞损伤的结果，根据特定的细胞类型和代谢状态，它们可能对组织和器官产生有害或有益的影响。随着衰老细胞在组织中随着年龄的增长而积累，它们与许多与年龄相关的衰退和疾病有关。衰老的主要方面包括负责建立和维持衰老程序的两条途径，即p53/CDKN1A（p21）和CDKN2A（p16）/RB，以及衰老相关分泌表型。许多微小RNA通过调节关键衰老调节蛋白的丰度来影响衰老，通常是通过降低编码此类因子的mRNA的稳定性和/或翻译。因此，了解微小RNA影响衰老的分子机制将为针对衰老细胞的诊断和治疗提供机会。在这里，我们综述了衰老相关（SA）-微小RNA，并讨论了它们在与衰老相关的病理学中的意义。
