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湿疹患者血浆中 IL-18 和 IL-18BP 的表达增强：肥大细胞上 IL-18BP 和 IL-18 受体表达改变。

Enhanced Expression of IL-18 and IL-18BP in Plasma of Patients with Eczema: Altered Expression of IL-18BP and IL-18 Receptor on Mast Cells.

机构信息

Allergy and Clinical Immunology Research Centre, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, China.

The PLA Center of Respiratory and Allergic Disease Diagnosing Management, General Hospital of Shenyang Military Area Command, Shenyang 110840, China.

出版信息

Mediators Inflamm. 2017;2017:3090782. doi: 10.1155/2017/3090782. Epub 2017 Aug 3.

DOI:10.1155/2017/3090782
PMID:28839348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5559929/
Abstract

IL-18 has been found to be associated with eczema. However, little is known of the role of IL-18 binding protein (BP) and IL-18 receptor (R) in eczema. We therefore investigated the expression of IL-18, IL-18BP, and IL-18R on mast cells by using flow cytometry analysis and mouse eczema model. The results showed that plasma free IL-18 and free IL-18BP levels in eczema patients were higher than those in healthy controls. IL-18 provoked up to 3.1-fold increase in skin mast cells. IL-18 induced also an increase in IL-18BP+ mast cells, but a reduction of IL-18R+ mast cells in mouse eczema skin. It was found that house dust mite allergen Der p1 and egg allergen OVA induced upregulation of the expression of IL-18, IL-18BP, and IL-18R mRNAs in HMC-1 cells following 2 and 16 h incubation. In conclusion, correlation of IL-18 and IL-18BP in eczema plasma suggests an important balance between IL-18 and IL-18BP in eczema. The decrease in molar concentration ratio of plasma IL-18BP/IL-18 and allergen-induced upregulated expression of IL-18 and IL-18R in skin mast cells of the patients with eczema suggests that anti-IL-18 including IL-18BP therapy may be useful for the treatment of eczema.

摘要

白细胞介素-18（IL-18）已被发现与湿疹有关。然而，IL-18 结合蛋白（BP）和 IL-18 受体（R）在湿疹中的作用知之甚少。因此，我们通过流式细胞术分析和小鼠湿疹模型研究了肥大细胞中 IL-18、IL-18BP 和 IL-18R 的表达。结果表明，湿疹患者的血浆游离 IL-18 和游离 IL-18BP 水平高于健康对照组。IL-18 可使皮肤肥大细胞增加高达 3.1 倍。IL-18 还诱导 IL-18BP+肥大细胞增加，但在小鼠湿疹皮肤中 IL-18R+肥大细胞减少。发现屋尘螨过敏原 Der p1 和卵清过敏原 OVA 诱导 HMC-1 细胞中 IL-18、IL-18BP 和 IL-18R mRNA 的表达在孵育 2 和 16 小时后上调。总之，湿疹患者血浆中 IL-18 和 IL-18BP 的相关性表明 IL-18 和 IL-18BP 之间在湿疹中存在重要的平衡。湿疹患者血浆中 IL-18BP/IL-18 摩尔浓度比下降和过敏原诱导的皮肤肥大细胞中 IL-18 和 IL-18R 表达上调表明，抗 IL-18 包括 IL-18BP 治疗可能对湿疹的治疗有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/3023920742d0/MI2017-3090782.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/572a79f853d0/MI2017-3090782.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/7b40fbf114ad/MI2017-3090782.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/7a771223ef1a/MI2017-3090782.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/b56dd8fb58ce/MI2017-3090782.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/19165ac8d7d2/MI2017-3090782.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/3023920742d0/MI2017-3090782.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/572a79f853d0/MI2017-3090782.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/7b40fbf114ad/MI2017-3090782.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/7a771223ef1a/MI2017-3090782.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/b56dd8fb58ce/MI2017-3090782.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/19165ac8d7d2/MI2017-3090782.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/698d/5559929/3023920742d0/MI2017-3090782.006.jpg

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