Key Laboratory for Organic Electronics and Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, Jiangsu, China.
Key Laboratory for Organic Electronics and Information Displays (KLOEID), Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, Jiangsu, China.
J Control Release. 2019 Jan 10;293:94-103. doi: 10.1016/j.jconrel.2018.11.016. Epub 2018 Nov 16.
Multifunctional drug delivery nanoplatform (PDPP3T@PSNiAA NPs) based on NIR absorbing semiconducting polymer nanoparticles for pH/NIR light-controllably regulated drug release has been successfully prepared. In this strategy, pH/thermal-sensitive multifunctional polymer polystyrene-b-poly(N-isopropylacrylamide-co-acrylic acid) (PSNiAA) was meticulously designed and synthesized using the reversible addition fragmentation chain transfer (RAFT) polymerization method. Furthermore, PSNiAA was used to functionalize diketopyrrolopyrrole-based semiconducting polymer (PDPP3T) to combine photothermal capacity and pH/thermo-responsive drug release in one entity. The prepared PDPP3T@PSNiAA NPs exhibited high photothermal conversion efficiency (η = 34.1%) and excellent photoacoustic (PA) brightness. Meanwhile, benefiting from the photothermal effect of PDPP3T and the pH/thermal-responsive properties of PSNiAA, Dox-loaded PDPP3T@PSNiAA NPs (PDPP3T@PSNiAA-Dox NPs) were able to controllably regulate the release of Dox by pH/NIR light, in which the enhanced drug release at acidic condition upon NIR irradiation phenomenon would minimize unnecessary drug release in normal tissues and was highly beneficial for precise synergistic chemo- and photothermal therapy.
基于近红外(NIR)吸收半导体聚合物纳米粒子的多功能药物递送纳米平台(PDPP3T@PSNiAA NPs)已成功制备，可实现 pH/NIR 光控调节药物释放。在该策略中，使用可逆加成-断裂链转移(RAFT)聚合方法精心设计并合成了 pH/热敏感多功能聚合物聚苯乙烯-b-聚(N-异丙基丙烯酰胺-co-丙烯酸)(PSNiAA)。此外，PSNiAA 被用于功能化基于二酮吡咯并吡咯(DPP)的半导体聚合物(PDPP3T)，将光热能力和 pH/热响应性药物释放结合在一个实体中。所制备的 PDPP3T@PSNiAA NPs 表现出高的光热转换效率(η=34.1%)和优异的光声(PA)亮度。同时，得益于 PDPP3T 的光热效应和 PSNiAA 的 pH/热响应特性，负载多柔比星(DOX)的 PDPP3T@PSNiAA NPs(PDPP3T@PSNiAA-Dox NPs)能够通过 pH/NIR 光来控制 DOX 的释放，其中在近红外照射下酸性条件下增强的药物释放现象将最小化在正常组织中不必要的药物释放，这非常有利于精确的协同化学和光热治疗。
