Portelli Marco, Militi Angela, Cervino Gabriele, Lauritano Floriana, Sambataro Sergio, Mainardi Alberto, Nucera Riccardo
Department of Biomedical, Dental Science and Morphological and Functional Images, Dental School, University of Messina, Messina, Italy.
Private Practice, Center Orthodontics and Gnathology (COS), Catania, Italy.
Open Dent J. 2017 Jun 30;11:257-265. doi: 10.2174/1874210601711010257. eCollection 2017.
Oxidative stress is a pathologic event induced by a prevalence of oxidant agents on the antioxidant ones, with a consequent alteration of oxide-reducing balance.
Freeradicals produce damages both in cellular and extra-cellular components; phospholipid membranes, proteins, mitochondrial and nuclear DNA, are the target of the oxidative stress, that can finally cause cellular death due to apoptosis.
MATERIALS & METHODS: Orthodontic appliances such as brackets, wires, resins and soldering have some components that can be considered as potential allergen, carcinogenic, cytotoxic and gene mutation factors. The primary aim of this research is to evaluate oxidative stress in the saliva of patients treated with multibracket self-ligating vestibular orthodontic appliances; the secondary purpose is to investigate the influence of orthodontic multibracket therapy on oral hygiene and the consequent effect on oxidative stress. Salivary specimens has been collected in a sample of 23 patients were enrolled (12 Female, 11 Male) between 12 and 16 years of age (mean age 14.2). For each patient has been collected a salivary specimen at the following time points; before orthodontic bonding (T1), five weeks (T2) and ten weeks (T3) after orthodontic appliance bonding.
Samples has been analysed with a photometer due to SAT Test (Salivary Antioxidant Test). Data obtained show a mean of 2971 mEq/l of anti-oxidant agents before orthodontic treatment, and after five weeks from the bonding the mean was decreased to 2909 mEq/l, instead at ten weeks was increased to 3332 mEq/l. Repeated measures ANOVA did not reveal statistically significant differences between the time points ( = 0.1697). The study did not reveal any correlation between the level of dental hygiene and that of oxidative stress (Pearson Correlation Coefficient R = 0).
Orthodontic treatment with multibrackets vestibular metallic appliance seems to be not able to affect oxidative stress during the first ten weeks of therapy.
氧化应激是一种由氧化剂在抗氧化剂中占优势引发的病理事件，进而导致氧化还原平衡的改变。
自由基会对细胞内和细胞外成分造成损害；磷脂膜、蛋白质、线粒体和核DNA都是氧化应激的靶点，最终可能导致细胞因凋亡而死亡。
正畸矫治器，如托槽、弓丝、树脂和焊接材料，其某些成分可被视为潜在的过敏原、致癌物、细胞毒性和基因突变因素。本研究的主要目的是评估使用多托槽自结扎前庭正畸矫治器治疗的患者唾液中的氧化应激；次要目的是研究正畸多托槽治疗对口腔卫生的影响以及对氧化应激的后续作用。收集了23名年龄在12至16岁（平均年龄14.2岁）的患者（12名女性，11名男性）的唾液样本。在以下时间点为每位患者收集唾液样本：正畸粘结前（T1）、正畸矫治器粘结后五周（T2）和十周（T3）。
由于进行了唾液抗氧化测试（SAT Test），样本使用光度计进行了分析。获得的数据显示，正畸治疗前抗氧化剂的平均含量为2971 mEq/l，粘结后五周平均降至2909 mEq/l，而在十周时升至3332 mEq/l。重复测量方差分析未显示各时间点之间存在统计学显著差异（ = 0.1697）。该研究未发现口腔卫生水平与氧化应激水平之间存在任何相关性（皮尔逊相关系数R = 0）。
在前十周的治疗中，使用多托槽前庭金属矫治器进行正畸治疗似乎无法影响氧化应激。
