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隐匿性巨细胞病毒感染所致的隐源性结肠炎

Cryptogenic colitis due to occult cytomegalovirus infection.

作者信息

Marks Daniel J B, Smith Philip J, Rahman Farooq Z, Miller Robert F, Ledermann Jonathan A, Bloom Stuart L

机构信息

Department of Medicine, University College London, London, UK.

Department of Gastroenterology, University College London Hospital, London, UK.

出版信息

Frontline Gastroenterol. 2011 Jan;2(1):57-62. doi: 10.1136/fg.2010.001990. Epub 2010 Sep 28.

DOI:10.1136/fg.2010.001990
PMID:28839583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5517193/
Abstract

Colitis secondary to cytomegalovirus infection is well recognised and usually straightforward to diagnose. Here two cases are reported in whom all initial investigations failed to demonstrate the presence of virus, with potential adverse consequences for its treatment. A case is made for empirical antiviral therapy despite negative investigations if clinical suspicion is high.

摘要

巨细胞病毒感染继发的结肠炎已得到充分认识,通常诊断并不困难。本文报告两例患者,其所有初始检查均未能证实病毒的存在,这可能对其治疗产生不良后果。如果临床怀疑度高,即使检查结果为阴性,也应进行经验性抗病毒治疗。

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本文引用的文献

1
Impact of valganciclovir on Epstein-Barr Virus polymerase chain reaction in pediatric liver transplantation: preliminary report.缬更昔洛韦对小儿肝移植中爱泼斯坦-巴尔病毒聚合酶链反应的影响:初步报告。
Transplant Proc. 2009 Apr;41(3):1038-40. doi: 10.1016/j.transproceed.2009.02.053.
2
Antiviral treatment of cytomegalovirus infection and resistant strains.巨细胞病毒感染及耐药菌株的抗病毒治疗
Expert Opin Pharmacother. 2009 Feb;10(2):191-209. doi: 10.1517/14656560802678138.
3
Prevalence of infectious pathogens in Crohn's disease.克罗恩病中感染性病原体的患病率。
Pathol Res Pract. 2009;205(4):223-30. doi: 10.1016/j.prp.2008.04.018. Epub 2009 Jan 30.
4
Acute cytomegalovirus infection is a risk factor in refractory and complicated inflammatory bowel disease.急性巨细胞病毒感染是难治性和复杂性炎症性肠病的一个危险因素。
Dig Dis Sci. 2009 Nov;54(11):2456-62. doi: 10.1007/s10620-008-0639-6. Epub 2008 Dec 18.
5
Efficacy and safety of valganciclovir in liver-transplanted children infected with Epstein-Barr virus.缬更昔洛韦对感染EB病毒的肝移植儿童的疗效及安全性
Liver Transpl. 2008 Aug;14(8):1185-93. doi: 10.1002/lt.21498.
6
Severe cytomegalovirus infection in apparently immunocompetent patients: a systematic review.免疫功能正常患者的严重巨细胞病毒感染:一项系统评价
Virol J. 2008 Mar 27;5:47. doi: 10.1186/1743-422X-5-47.
7
Cytomegalovirus is frequently reactivated and disappears without antiviral agents in ulcerative colitis patients.巨细胞病毒在溃疡性结肠炎患者中经常重新激活,且在没有抗病毒药物的情况下会消失。
Am J Gastroenterol. 2007 Feb;102(2):331-7. doi: 10.1111/j.1572-0241.2006.00989.x. Epub 2006 Dec 11.
8
Seroprevalence of cytomegalovirus infection in the United States, 1988-1994.1988 - 1994年美国巨细胞病毒感染的血清流行率
Clin Infect Dis. 2006 Nov 1;43(9):1143-51. doi: 10.1086/508173. Epub 2006 Oct 2.
9
Cytomegalovirus colitis complicating inflammatory bowel disease.巨细胞病毒性结肠炎并发炎症性肠病。
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10
Ganciclovir and the treatment of Epstein-Barr virus hepatitis.更昔洛韦与爱泼斯坦-巴尔病毒肝炎的治疗
J Gastroenterol Hepatol. 2006 Nov;21(11):1758-60. doi: 10.1111/j.1440-1746.2006.03257.x.