更昔洛韦与爱泼斯坦-巴尔病毒肝炎的治疗

Ganciclovir and the treatment of Epstein-Barr virus hepatitis.

作者信息

Adams Leon A, Deboer Bastiaan, Jeffrey Gary, Marley Richard, Garas George

机构信息

Department of Gastroenterology and Hepatology, Sir Charles Gardiner Hospital, Nedlands, WA, Australia.

出版信息

J Gastroenterol Hepatol. 2006 Nov;21(11):1758-60. doi: 10.1111/j.1440-1746.2006.03257.x.

DOI:10.1111/j.1440-1746.2006.03257.x

PMID:16984606

Abstract

Epstein-Barr virus (EBV) is part of the herpesvirus family that infects up to 90% of the population. Initial infection is often subclincal in children but will generally result in symptomatic infectious mononucleosis in adolescents and adults. Ganciclovir has been utilized in immunocompromised patients with EBV encephalitis and post-liver transplant for EBV fulminant hepatitis. Herein, the successful use of ganciclovir in two immunocompetent patients with severe EBV hepatitis is reported.

摘要

爱泼斯坦-巴尔病毒（EBV）是疱疹病毒家族的一部分，感染人群高达90%。儿童初次感染通常无明显症状，但在青少年和成人中一般会导致有症状的传染性单核细胞增多症。更昔洛韦已用于患有EBV脑炎的免疫功能低下患者以及肝移植后发生EBV暴发性肝炎的患者。在此，报告了更昔洛韦在两名免疫功能正常的严重EBV肝炎患者中的成功应用。