Taha Ali S, Kelly Claire, McCloskey Caroline, Craigen Theresa, Angerson Wilson J
Department of Gastroenterology, University Hospital Crosshouse, Kilmarnock, Scotland, UK.
Department of Medicine, University of Glasgow, Kilmarnock, Scotland, UK.
Frontline Gastroenterol. 2013 Apr;4(2):108-111. doi: 10.1136/flgastro-2012-100280. Epub 2013 Jan 23.
In recent years, policies have been proposed in order to guide the safer use of non-steroidal anti-inflammatory drugs (NSAIDs) and antiulcer therapy. We aimed to investigate the incidence of upper gastrointestinal bleeding (UGIB) before and after the introduction of these policies, 2007-2009, in a well-defined population in southwest Scotland.
All patients with non-variceal upper gastrointestinal bleeding (NV-UGIB), diagnosed at a single regional unit, were included. Total drugs prescribed in our population were noted, including antiulcer drugs, antithrombotic drugs and both cyclo-oxygenase-2 enzyme-selective and non-selective inhibiting NSAIDs.
The incidence, the number of cases per 100 000 population per annum, of NV-UGIB fell from 134.7 in 2007 to 125.1 in 2008, and to 90.3 cases in 2009 (p<0.001). There was also a significant rise in the use of non-selective NSAIDs, proton pump inhibitors and antithrombotic drugs.
Although a cause-and-effect relationship cannot be fully proven, physician education through drug-use policies is associated with a drop in the incidence of NV-UGIB. This is relevant to the prevention of this common condition.
近年来，已出台相关政策以指导非甾体抗炎药（NSAIDs）的安全使用及抗溃疡治疗。我们旨在调查2007 - 2009年在苏格兰西南部一个明确界定的人群中实施这些政策前后上消化道出血（UGIB）的发生率。
纳入在单个区域单位诊断的所有非静脉曲张性上消化道出血（NV - UGIB）患者。记录我们人群中开具的所有药物，包括抗溃疡药物、抗血栓药物以及环氧化酶 - 2酶选择性和非选择性抑制NSAIDs。
NV - UGIB的发生率（每年每10万人口中的病例数）从2007年的134.7降至2008年的125.1，并在2009年降至90.3例（p<0.001）。非选择性NSAIDs、质子泵抑制剂和抗血栓药物的使用也显著增加。
尽管因果关系不能完全得到证实，但通过药物使用政策对医生进行教育与NV - UGIB发生率的下降有关。这对于预防这种常见病症具有重要意义。
