Cervone Mario
Small Animal Veterinary Clinic, Marseille, France.
JFMS Open Rep. 2017 Jul 21;3(2):2055116917719209. doi: 10.1177/2055116917719209. eCollection 2017 Jul-Dec.
Herein a drug-resistant IgG-lambda-type multiple myeloma associated with probable phaeochromocytoma in a cat is described. A 12-year-old cat presented with weakness, weight loss, progressive blindness and open-mouth breathing, in addition to polyuria and polydipsia of 2 months' duration. Abdominal ultrasonography revealed a left adrenal mass. Phaeochromocytoma was suspected on the basis of cytology and was associated with systemic hypertension. Biochemistry showed hyperproteinaemia. Serum protein electrophoresis revealed a narrow spike in the gamma region, identified as IgG lambda type at immunoelectrophoresis. Bone marrow cytology revealed an infiltrate with numerous mature plasma cells. The cat was resistant to two different drugs for multiple myeloma and was euthanased 6 months later because of anorexia and persistent poor general condition.
This is the first clinical description of multiple myeloma associated with a suspected phaeochromocytoma in a cat.
本文描述了一只猫身上出现的与疑似嗜铬细胞瘤相关的耐药性IgG-λ型多发性骨髓瘤。一只12岁的猫出现虚弱、体重减轻、进行性失明和张口呼吸,此外还有持续2个月的多尿和多饮症状。腹部超声检查发现左肾上腺有肿块。根据细胞学检查怀疑为嗜铬细胞瘤,并伴有系统性高血压。生化检查显示高蛋白血症。血清蛋白电泳显示γ区有一条窄峰,免疫电泳鉴定为IgG λ型。骨髓细胞学检查显示有大量成熟浆细胞浸润。这只猫对两种不同的多发性骨髓瘤药物耐药,6个月后因厌食和全身状况持续不佳而实施安乐死。
这是猫身上疑似嗜铬细胞瘤相关多发性骨髓瘤的首例临床描述。