• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过时域近红外光谱法测量新生儿大脑光学特性和血流动力学参数

measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy.

作者信息

Spinelli Lorenzo, Zucchelli Lucia, Contini Davide, Caffini Matteo, Mehler Jacques, Fló Ana, Ferry Alissa L, Filippin Luca, Macagno Francesco, Cattarossi Luigi, Torricelli Alessandro

机构信息

CNR, Istituto di Fotonica e Nanotecnologie, Milano, Italy.

Politecnico di Milano, Dipartimento di Fisica, Milano, Italy.

出版信息

Neurophotonics. 2017 Oct;4(4):041414. doi: 10.1117/1.NPh.4.4.041414. Epub 2017 Aug 18.

DOI:10.1117/1.NPh.4.4.041414
PMID:28840165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5561670/
Abstract

By exploiting a multichannel portable instrument for time-domain near-infrared spectroscopy (TD-NIRS), we characterized healthy neonates' brains in term of optical properties and hemodynamic parameters. In particular, we assessed the absolute values of the absorption and reduced scattering coefficients at two wavelengths, together with oxy-, deoxy- and total hemoglobin concentrations, and the blood oxygen saturation of the neonates' brains. In this study, 33 healthy full-term neonates were tested, obtaining the following median values: 0.28 and [Formula: see text] for [Formula: see text] at 690 and 820 nm, respectively; 5.8 and [Formula: see text] for [Formula: see text] at 690 and 820 nm, respectively; [Formula: see text] for [Formula: see text]; [Formula: see text] for [Formula: see text]; [Formula: see text] for [Formula: see text]; 72% for [Formula: see text]. In general, the agreement of these values with the sparse existing literature appears not always consistent. These findings demonstrate the first measurements of optical properties of the healthy neonate brain using TD-NIRS and show the need for clarification of optical properties across methods and populations.

摘要

通过利用一种用于时域近红外光谱（TD-NIRS）的多通道便携式仪器，我们从光学特性和血液动力学参数方面对健康新生儿的大脑进行了表征。具体而言，我们评估了两个波长下吸收系数和约化散射系数的绝对值，以及新生儿大脑的氧合血红蛋白、脱氧血红蛋白和总血红蛋白浓度，还有血氧饱和度。在本研究中，对33名健康足月儿进行了测试，得到以下中位数：690和820nm处的μa分别为0.28和[公式：见原文]；690和820nm处的μ's分别为5.8和[公式：见原文]；[公式：见原文]的HbO₂为[公式：见原文]；[公式：见原文]的HbR为[公式：见原文]；[公式：见原文]的HHb为[公式：见原文]；[公式：见原文]的StO₂为72%。总体而言，这些值与现有的少量文献的一致性似乎并不总是一致的。这些发现展示了使用TD-NIRS对健康新生儿大脑光学特性的首次测量，并表明需要明确不同方法和人群的光学特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/597619629e16/NPh-004-041414-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/102b111b78e0/NPh-004-041414-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/936477a475de/NPh-004-041414-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/c9a2666b1bee/NPh-004-041414-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/bafd0016f267/NPh-004-041414-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/597619629e16/NPh-004-041414-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/102b111b78e0/NPh-004-041414-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/936477a475de/NPh-004-041414-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/c9a2666b1bee/NPh-004-041414-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/bafd0016f267/NPh-004-041414-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a830/5561670/597619629e16/NPh-004-041414-g005.jpg

相似文献

1
measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy.通过时域近红外光谱法测量新生儿大脑光学特性和血流动力学参数
Neurophotonics. 2017 Oct;4(4):041414. doi: 10.1117/1.NPh.4.4.041414. Epub 2017 Aug 18.
2
Effect of assuming constant tissue scattering on measured tissue oxygenation values during tissue ischemia and vascular reperfusion.在组织缺血和血管再灌注期间，假设组织散射恒定对测量的组织氧合值的影响。
J Appl Physiol (1985). 2019 Jul 1;127(1):22-30. doi: 10.1152/japplphysiol.01138.2018. Epub 2019 Apr 18.
3
Long-Term Changes in Optical Properties (μ, μ', μ and DPF) of Human Head Tissue During Functional Neuroimaging Experiments.在功能神经影像学实验中，人头部组织的光学性质（μ、μ'、μ 和 DPF）的长期变化。
Adv Exp Med Biol. 2018;1072:331-337. doi: 10.1007/978-3-319-91287-5_53.
4
Absolute Values of Optical Properties (μ, μ΄, μ and DPF) of Human Head Tissue: Dependence on Head Region and Individual.人体头部组织光学特性（μ、μ'、μ 和 DPF）的绝对值：与头部区域和个体的关系。
Adv Exp Med Biol. 2018;1072:325-330. doi: 10.1007/978-3-319-91287-5_52.
5
Accuracy of oxygen saturation and total hemoglobin estimates in the neonatal brain using the semi-infinite slab model for FD-NIRS data analysis.使用半无限平板模型进行频域近红外光谱（FD-NIRS）数据分析时，新生儿大脑中氧饱和度和总血红蛋白估计值的准确性。
Biomed Opt Express. 2014 Nov 14;5(12):4300-12. doi: 10.1364/BOE.5.004300. eCollection 2014 Dec 1.
6
Differential pathlength factor informs evoked stimulus response in a mouse model of Alzheimer's disease.差分光程因子可反映阿尔茨海默病小鼠模型中的诱发刺激反应。
Neurophotonics. 2015 Oct;2(4):045001. doi: 10.1117/1.NPh.2.4.045001. Epub 2015 Oct 12.
7
In vivo determination of the optical properties of infant brain using frequency-domain near-infrared spectroscopy.
J Biomed Opt. 2005 Mar-Apr;10(2):024028. doi: 10.1117/1.1891345.
8
Effects of hypothermia, hypoxia, and hypercapnia on brain oxygenation and hemodynamic parameters during simulated avalanche burial: a porcine study.模拟雪崩掩埋过程中低温、缺氧和高碳酸血症对脑氧合和血流动力学参数的影响：一项猪研究。
J Appl Physiol (1985). 2021 Jan 1;130(1):237-244. doi: 10.1152/japplphysiol.00498.2020. Epub 2020 Nov 5.
9
Indexing cerebrovascular health using near-infrared spectroscopy.利用近红外光谱对脑血管健康进行指标检测。
Sci Rep. 2021 Jul 20;11(1):14812. doi: 10.1038/s41598-021-94348-5.
10
NIRS-based cerebrovascular regulation assessment: exercise and cerebrovascular reactivity.基于近红外光谱技术的脑血管调节评估：运动与脑血管反应性
Neurophotonics. 2017 Oct;4(4):041503. doi: 10.1117/1.NPh.4.4.041503. Epub 2017 Sep 12.

引用本文的文献

1
Cerebral baseline optical and hemodynamic properties in pediatric population: a large cohort time-domain near-infrared spectroscopy study.儿童群体的脑基线光学和血流动力学特性：一项大型队列时域近红外光谱研究。
Neurophotonics. 2024 Oct;11(4):045009. doi: 10.1117/1.NPh.11.4.045009. Epub 2024 Nov 15.
2
Use of bioresorbable fibers for short-wave infrared spectroscopy using time-domain diffuse optics.用于时域漫射光学的短波红外光谱分析的生物可吸收纤维的应用。
Biomed Opt Express. 2024 Aug 5;15(9):5041-5052. doi: 10.1364/BOE.531681. eCollection 2024 Sep 1.
3
Optical Monitoring in Neonatal Seizures.

本文引用的文献

1
In-vivo multilaboratory investigation of the optical properties of the human head.人体头部光学特性的体内多实验室研究。
Biomed Opt Express. 2015 Jun 18;6(7):2609-23. doi: 10.1364/BOE.6.002609. eCollection 2015 Jul 1.
2
Twenty years of functional near-infrared spectroscopy: introduction for the special issue.二十年的功能性近红外光谱学：特刊介绍。
Neuroimage. 2014 Jan 15;85 Pt 1:1-5. doi: 10.1016/j.neuroimage.2013.11.033.
3
Time domain functional NIRS imaging for human brain mapping.时域功能近红外光谱成像在人脑映射中的应用。
新生儿惊厥的光学监测。
Cells. 2022 Aug 21;11(16):2602. doi: 10.3390/cells11162602.
4
Correlating functional near-infrared spectroscopy with underlying cortical regions of 0-, 1-, and 2-year-olds using theoretical light propagation analysis.使用理论光传播分析将功能性近红外光谱与0岁、1岁和2岁儿童的潜在皮质区域相关联。
Neurophotonics. 2021 Apr;8(2):025009. doi: 10.1117/1.NPh.8.2.025009. Epub 2021 May 31.
5
Accuracy of homogeneous models for photon diffusion in estimating neonatal cerebral hemodynamics by TD-NIRS.用于通过时域近红外光谱技术（TD-NIRS）估计新生儿脑血流动力学的光子扩散均匀模型的准确性。
Biomed Opt Express. 2021 Mar 8;12(4):1905-1921. doi: 10.1364/BOE.417357. eCollection 2021 Apr 1.
6
Absolute quantification of cerebral tissue oxygen saturation with multidistance broadband NIRS in newborn brain.采用多距离宽带近红外光谱技术对新生儿大脑脑组织氧饱和度进行绝对定量分析。
Biomed Opt Express. 2021 Jan 15;12(2):907-925. doi: 10.1364/BOE.412088. eCollection 2021 Feb 1.
7
Functional near infrared spectroscopy using spatially resolved data to account for tissue scattering: A numerical study and arm-cuff experiment.使用空间分辨数据来解释组织散射的功能近红外光谱：数值研究和臂套实验。
J Biophotonics. 2019 Oct;12(10):e201900064. doi: 10.1002/jbio.201900064. Epub 2019 Jun 23.
8
High-density diffuse optical tomography for imaging human brain function.用于人脑功能成像的高密度扩散光学断层扫描技术。
Rev Sci Instrum. 2019 May;90(5):051101. doi: 10.1063/1.5086809.
9
Accuracy and precision of tissue optical properties and hemodynamic parameters estimated by the BabyLux device: a hybrid time-resolved near-infrared and diffuse correlation spectroscopy neuro-monitor.BabyLux设备估计的组织光学特性和血流动力学参数的准确性和精密度：一种混合时间分辨近红外和扩散相关光谱神经监测仪
Biomed Opt Express. 2019 Apr 25;10(5):2556-2579. doi: 10.1364/BOE.10.002556. eCollection 2019 May 1.
10
Frequency analysis of oscillations in cerebral hemodynamics measured by time domain near infrared spectroscopy.通过时域近红外光谱法测量的脑血流动力学振荡的频率分析
Biomed Opt Express. 2019 Jan 23;10(2):761-771. doi: 10.1364/BOE.10.000761. eCollection 2019 Feb 1.
Neuroimage. 2014 Jan 15;85 Pt 1:28-50. doi: 10.1016/j.neuroimage.2013.05.106. Epub 2013 Jun 5.
4
An online database of infant functional near infrared spectroscopy studies: a community-augmented systematic review.婴儿功能近红外光谱研究在线数据库：社区增强式系统评价。
PLoS One. 2013;8(3):e58906. doi: 10.1371/journal.pone.0058906. Epub 2013 Mar 15.
5
Fully automated spatially resolved reflectance spectrometer for the determination of the absorption and scattering in turbid media.用于测定混浊介质中吸收和散射的全自动化空间分辨反射光谱仪。
Rev Sci Instrum. 2011 Oct;82(10):103104. doi: 10.1063/1.3648120.
6
Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain.近红外光谱评估早产儿脑发育中的脑氧代谢。
J Cereb Blood Flow Metab. 2012 Mar;32(3):481-8. doi: 10.1038/jcbfm.2011.145. Epub 2011 Oct 26.
7
Studying neonates' language and memory capacities with functional near-infrared spectroscopy.使用功能近红外光谱技术研究新生儿的语言和记忆能力。
Front Psychol. 2011 Apr 18;2:64. doi: 10.3389/fpsyg.2011.00064. eCollection 2011.
8
Precision of cerebral oxygenation and hemoglobin concentration measurements in neonates measured by near-infrared spectroscopy.近红外光谱法测量新生儿脑氧合和血红蛋白浓度的精度。
J Biomed Opt. 2011 Apr;16(4):047005. doi: 10.1117/1.3570303.
9
A brief review on the use of functional near-infrared spectroscopy (fNIRS) for language imaging studies in human newborns and adults.简要综述功能性近红外光谱（fNIRS）在人类新生儿和成人语言成像研究中的应用。
Brain Lang. 2012 May;121(2):79-89. doi: 10.1016/j.bandl.2011.03.009. Epub 2011 Apr 19.
10
Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult.评估频域多距离方法以评估大脑光学特性：从新生儿到成人的蒙特卡罗模拟
Biomed Opt Express. 2011 Feb 11;2(3):552-67. doi: 10.1364/BOE.2.000552.