Calcaterra Valeria, Lacerenza Michele, Amendola Caterina, Buttafava Mauro, Contini Davide, Rossi Virginia, Spinelli Lorenzo, Zanelli Sara, Zuccotti Gianvincenzo, Torricelli Alessandro
Buzzi Children's Hospital, Pediatric Department, Milan, Italy.
University of Pavia, Pediatric and Adolescent Unit, Department of Internal Medicine, Pavia, Italy.
Neurophotonics. 2024 Oct;11(4):045009. doi: 10.1117/1.NPh.11.4.045009. Epub 2024 Nov 15.
Reference cerebral near-infrared spectroscopy (NIRS) data on the pediatric population are scarce, and in most cases, only cerebral oxygen saturation ( ) measured by continuous wave spatially resolved spectroscopy NIRS is reported. Absolute data for baseline optical and hemodynamic parameters are missing.
We aimed at collecting baseline cerebral optical parameters [absorption coefficient, ; reduced scattering coefficient, ; differential pathlength factor (DPF)] and hemodynamic parameters [oxy-hemoglobin content ( ), deoxyhemoglobin content (HHb), total hemoglobin content (tHB), ] in a large cohort of pediatric patients. The objectives are to establish reference optical values in this population and evaluate the reproducibility of a commercial time domain (TD) NIRS tissue oximeter.
TD NIRS measurements were performed in the prefrontal cortex at 686 and 830 nm with a 2.5-cm source-detector distance and 1-Hz acquisition rate. Five independent measurements (after probe replacement) were taken for every subject. TD NIRS data were fitted to a photon diffusion model to estimate the optical parameters. From the absorption coefficients, the hemodynamic parameters were derived by Beer's law. Auxological and physiological information was also collected to explore the potential correlations with NIRS data.
We measured 305 patients in the age range of 2 to 18 years. Absolute values for baseline optical and hemodynamic parameters were shown as a function of age and auxological variables. From the analysis of the repositioning after probe replacement, the time-domain near-infrared spectroscopy device exhibited an average precision (intended as coefficient of variation) of for , DPF, , HHb, and tHb, whereas precision was for .
We provided baseline values for optical and hemodynamic parameters in a large cohort of healthy pediatric subjects with good precision, providing a foundation for future investigations into clinically relevant deviations in these parameters.
关于儿科人群的参考脑近红外光谱（NIRS）数据稀缺，并且在大多数情况下，仅报告了通过连续波空间分辨光谱NIRS测量的脑氧饱和度（ ）。基线光学和血流动力学参数的绝对数据缺失。
我们旨在收集一大群儿科患者的基线脑光学参数[吸收系数， ；约化散射系数， ；微分路径长度因子（DPF）]和血流动力学参数[氧合血红蛋白含量（ ）、脱氧血红蛋白含量（HHb）、总血红蛋白含量（tHB）， ]。目标是建立该人群的参考光学值，并评估商用时域（TD）NIRS组织血氧仪的可重复性。
在额叶皮层以686和830 nm进行TD NIRS测量，源 - 探测器距离为2.5 cm，采集速率为1 Hz。对每个受试者进行五次独立测量（更换探头后）。将TD NIRS数据拟合到光子扩散模型以估计光学参数。根据吸收系数，通过比尔定律推导出血流动力学参数。还收集了人体测量学和生理学信息，以探索与NIRS数据的潜在相关性。
我们测量了305名年龄在2至18岁之间的患者。基线光学和血流动力学参数的绝对值显示为年龄和人体测量学变量的函数。通过对探头更换后的重新定位分析，时域近红外光谱设备对 、DPF、 、HHb和tHb的平均精度（定义为变异系数）为 ，而对 的精度为 。
我们为一大群健康儿科受试者提供了光学和血流动力学参数的基线值，精度良好，为未来研究这些参数的临床相关偏差奠定了基础。
