Kosaka T, Heizmann C W, Tateishi K, Hamaoka Y, Hama K
Brain Res. 1987 Apr 21;409(2):403-8. doi: 10.1016/0006-8993(87)90732-3.
The possibility of the colocalization of a Ca2+-binding protein, parvalbumin (PV), with peptides, cholecystokinin (CCK) and somatostatin (SS), all of which are known to be contained gamma-aminobutyric acidergic neurons in the cerebral cortex, was tested in the rat visual cortex by means of immunohistochemistry using the adjacent section technique. No PV immunoreactive (PV-I) neurons showed CCK-like immunoreactivity, and almost none (932 out of 934 PV-I neurons examined) showed SS-like immunoreactivity. These observations suggest that the GABAergic system of the cerebral cortex may consist of some distinct subsystems with different chemical and presumably physiological characteristics.
通过使用相邻切片技术的免疫组织化学方法，在大鼠视觉皮层中检测了一种钙结合蛋白——小白蛋白（PV）与肽类——胆囊收缩素（CCK）和生长抑素（SS）共定位的可能性，已知这些物质都存在于大脑皮层的γ-氨基丁酸能神经元中。没有PV免疫反应阳性（PV-I）神经元显示出CCK样免疫反应性，并且几乎没有（在检查的934个PV-I神经元中932个）显示出SS样免疫反应性。这些观察结果表明，大脑皮层的GABA能系统可能由一些具有不同化学和推测生理特征的不同子系统组成。
