Eichenbaum Howard
Center for Memory and Brain, Boston University, 2 Cummington Mall, Boston MA 02215.
Curr Opin Behav Sci. 2017 Oct;17:65-70. doi: 10.1016/j.cobeha.2017.06.010.
There is considerable recent evidence that, in addition to its representation of space, the hippocampus also represents the temporal organization of memories. Time plays a central role in episodic memory, and studies have identified the hippocampus as playing an essential role in the temporal organization of memories in humans and animals. Temporal organization is supported by a gradually changing temporal context signal in the hippocampus, and this changing context signal involves "time cells" in the hippocampus that code sequential moments in temporally organized experiences. Finally, hippocampal temporal context representations mechanisms in intrinsic circuitry and oscillatory patterns throughout hippocampal subfields and likely depend on inputs from parahippocampal cortical areas and a widespread temporal processing system in the neocortex.
最近有大量证据表明,海马体除了表征空间外,还表征记忆的时间组织。时间在情景记忆中起着核心作用,研究已确定海马体在人类和动物记忆的时间组织中起着至关重要的作用。海马体中逐渐变化的时间背景信号支持了时间组织,而这种不断变化的背景信号涉及海马体中的“时间细胞”,这些细胞对时间组织经验中的连续时刻进行编码。最后,海马体时间背景表征机制存在于整个海马体子区域的内在神经回路和振荡模式中,并且可能依赖于海马旁皮质区域的输入以及新皮质中广泛存在的时间处理系统。