• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Induction of gamma-glutamyl transpeptidase mRNA by aflatoxin B1 and ethoxyquin in rat liver.

作者信息

Power C A, Griffiths S A, Simpson J L, Laperche Y, Guellaen G, Manson M M

出版信息

Carcinogenesis. 1987 May;8(5):737-40. doi: 10.1093/carcin/8.5.737.

DOI:10.1093/carcin/8.5.737
PMID:2884051
Abstract

We have studied the induction of rat liver gamma-glutamyl transpeptidase (GGT) mRNA by the antioxidant ethoxyquin and during aflatoxin B1-induced carcinogenesis. Using a rat kidney GGT cDNA probe, Northern blot analysis revealed that GGT mRNA induced in liver by either compounds was slightly larger than that found in untreated kidney. GGT mRNA was not detected in untreated liver or freshly isolated hepatocytes, but induction of the message in treated tissues correlated with the increase in enzymic activity observed by histochemistry and quantitative assay. Slot-blot analysis of poly(A)+ mRNA indicated that constitutive GGT mRNA levels in kidney were at least 5-fold greater than those in the most GGT-positive liver-derived tissue examined.

摘要

相似文献

1
Induction of gamma-glutamyl transpeptidase mRNA by aflatoxin B1 and ethoxyquin in rat liver.
Carcinogenesis. 1987 May;8(5):737-40. doi: 10.1093/carcin/8.5.737.
2
Characterization of a promoter for gamma-glutamyl transpeptidase activated in rat liver in response to aflatoxin B1 and ethoxyquin.黄曲霉毒素B1和乙氧喹啉诱导大鼠肝脏中γ-谷氨酰转肽酶启动子的特性研究
Mol Carcinog. 1995 Dec;14(4):251-62. doi: 10.1002/mc.2940140405.
3
Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.乙氧喹啉喂养大鼠中黄曲霉毒素代谢、黄曲霉毒素-N7-鸟嘌呤形成及肝脏肿瘤发生的调节：谷胱甘肽S-转移酶诱导的作用。
Cancer Res. 1986 Aug;46(8):3924-31.
4
Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat.抗氧化剂乙氧喹对大鼠黄曲霉毒素B1肝癌发生保护作用的代谢基础。
Cancer Res. 1987 Oct 1;47(19):5218-23.
5
Ethoxyquin alone induces preneoplastic changes in rat kidney whilst preventing induction of such lesions in liver by aflatoxin B1.
Carcinogenesis. 1987 May;8(5):723-8. doi: 10.1093/carcin/8.5.723.
6
Rat liver gamma glutamyl transpeptidase mRNA differs in the 5' untranslated sequence from the corresponding kidney mRNA.大鼠肝脏γ-谷氨酰转肽酶信使核糖核酸在5'非翻译序列上与相应的肾脏信使核糖核酸不同。
Cancer Lett. 1989 Jul 1;46(1):69-74. doi: 10.1016/0304-3835(89)90217-6.
7
The influence of partial hepatectomy on the biphasic response of gamma glutamyl transpeptidase to aflatoxin B1.部分肝切除对γ-谷氨酰转肽酶对黄曲霉毒素B1双相反应的影响。
Cancer Lett. 1984 Nov;25(1):81-7. doi: 10.1016/s0304-3835(84)80029-4.
8
Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia.化学预防剂及黄曲霉毒素B1诱导的癌前病变对大鼠谷氨酸-半胱氨酸连接酶（γ-谷氨酰半胱氨酸合成酶）亚基的调控
Carcinogenesis. 2000 Oct;21(10):1827-34. doi: 10.1093/carcin/21.10.1827.
9
Expression of multiple proteins structurally related to gamma-glutamyl transpeptidase in non-neoplastic adult rat hepatocytes in vivo and in culture.与γ-谷氨酰转肽酶结构相关的多种蛋白质在成年大鼠非肿瘤性肝细胞体内及体外培养中的表达
J Cell Physiol. 1991 Feb;146(2):234-41. doi: 10.1002/jcp.1041460207.
10
The inhibitory effects of ethoxyquin on the carcinogenic action of aflatoxin B1 in rats.乙氧喹对大鼠黄曲霉毒素B1致癌作用的抑制效果。
Cancer Lett. 1983 Jun;19(2):125-32. doi: 10.1016/0304-3835(83)90146-5.

引用本文的文献

1
Differential expression of the rat gamma-glutamyl transpeptidase gene promoters along with differentiation of hepatoblasts into biliary or hepatocytic lineage.大鼠γ-谷氨酰转肽酶基因启动子的差异表达与肝母细胞向胆管或肝细胞谱系的分化过程相伴。
Am J Pathol. 2000 Aug;157(2):537-48. doi: 10.1016/s0002-9440(10)64564-6.
2
The gamma-glutamyl transpeptidase gene is transcribed from a different promoter in rat hepatocytes and biliary cells.γ-谷氨酰转肽酶基因在大鼠肝细胞和胆管细胞中由不同的启动子转录。
Am J Pathol. 1998 Apr;152(4):1039-48.
3
Expression of multiple gamma-glutamyltransferase genes in man.
人多种γ-谷氨酰转移酶基因的表达
Biochem J. 1994 Feb 1;297 ( Pt 3)(Pt 3):503-8. doi: 10.1042/bj2970503.
4
Regulation of mouse mammary-gland gamma-glutamyltranspeptidase mRNA during pregnancy, lactation and weaning.小鼠乳腺γ-谷氨酰转肽酶mRNA在怀孕、哺乳和断奶期间的调控
Biochem J. 1990 May 1;267(3):621-4. doi: 10.1042/bj2670621.
5
Identification of a human gamma-glutamyl cleaving enzyme related to, but distinct from, gamma-glutamyl transpeptidase.一种与γ-谷氨酰转肽酶相关但不同的人γ-谷氨酰裂解酶的鉴定。
Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6303-7. doi: 10.1073/pnas.88.14.6303.
6
Tissue- and developmental-stage-specific methylation in the two kidney promoters of the rat gamma-glutamyl transpeptidase gene.大鼠γ-谷氨酰转肽酶基因两个肾脏启动子中的组织和发育阶段特异性甲基化
Biochem J. 1992 Nov 1;287 ( Pt 3)(Pt 3):691-4. doi: 10.1042/bj2870691.