Cabral J R, Neal G E
Cancer Lett. 1983 Jun;19(2):125-32. doi: 10.1016/0304-3835(83)90146-5.
Ethoxyquin (EQ), a widely used antioxidant, inhibits the carcinogenic effects of polycyclic aromatic hydrocarbons. The aim of the present study was to determine whether EQ modifies the hepatocarcinogenic effects of aflatoxin B1 (AFB1) in rats. Both compounds were administered in the diet. Rats were fed either EQ for 2 weeks and then AFB1 for 6 weeks, EQ and AFB1 simultaneously or EQ following the cessation of AFB1 treatment. The results indicate that EQ can inhibit the hepatocarcinogenic effects of AFB1 and that the most effective inhibition is obtained when EQ and AFB1 are given simultaneously.
乙氧喹（EQ）是一种广泛使用的抗氧化剂，可抑制多环芳烃的致癌作用。本研究的目的是确定EQ是否能改变黄曲霉毒素B1（AFB1）对大鼠的肝癌致癌作用。两种化合物均通过饮食给予。给大鼠喂食EQ 2周，然后喂食AFB1 6周，或同时喂食EQ和AFB1，或在停止AFB1治疗后喂食EQ。结果表明，EQ可抑制AFB1的肝癌致癌作用，并且当同时给予EQ和AFB1时可获得最有效的抑制效果。
