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Clonal evolution is a prognostic factor for the clinical progression of monoclonal B-cell lymphocytosis.

作者信息

Kostopoulos I V, Paterakis G, Pavlidis D, Kastritis E, Terpos E, Tsitsilonis O E, Papadhimitriou S I

机构信息

Hematology Laboratory, 'G. Gennimatas' Athens General Hospital, Athens, Greece.

Section of Animal and Human Physiology, Department of Biology, National and Kapodistrian University of Athens, Athens, Greece.

出版信息

Blood Cancer J. 2017 Aug 25;7(8):e597. doi: 10.1038/bcj.2017.77.

DOI:10.1038/bcj.2017.77
PMID:28841209
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5596387/
Abstract
摘要

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Blood Cancer J. 2017 Aug 25;7(8):e597. doi: 10.1038/bcj.2017.77.
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Prospective study of prognostic factors in asymptomatic patients with B-cell chronic lymphocytic leukemia-like lymphocytosis: the cut-off of 11 × 10(9)/L monoclonal lymphocytes better identifies subgroups with different outcomes.B细胞慢性淋巴细胞白血病样淋巴细胞增多症无症状患者预后因素的前瞻性研究:11×10⁹/L单克隆淋巴细胞的临界值能更好地识别具有不同预后的亚组。
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本文引用的文献

1
Immunophenotypic analysis reveals heterogeneity and common biologic aspects in monoclonal B-cell lymphocytosis.免疫表型分析揭示了单克隆B细胞淋巴细胞增多症中的异质性和共同生物学特征。
Genes Chromosomes Cancer. 2015 Apr;54(4):210-21. doi: 10.1002/gcc.22234. Epub 2014 Dec 23.
2
The microenvironment in lymphomas--dissecting the complex crosstalk between tumor cells and 'by-stander' cells.淋巴瘤的微环境——剖析肿瘤细胞与“旁观者”细胞之间复杂的串扰。
Semin Cancer Biol. 2014 Feb;24:1-2. doi: 10.1016/j.semcancer.2013.12.002. Epub 2013 Dec 21.
3
General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL.
一般人群中低计数 CLL 样 MBL 会持续存在,尽管具有与 CLL 相同的细胞遗传学异常,但不会出现临床进展。
Blood. 2011 Dec 15;118(25):6618-25. doi: 10.1182/blood-2011-05-357251. Epub 2011 Aug 29.
4
Non-CLL-like monoclonal B-cell lymphocytosis in the general population: prevalence and phenotypic/genetic characteristics.普通人群中非 CLL 样单克隆 B 细胞淋巴增生症:患病率及表型/遗传学特征。
Cytometry B Clin Cytom. 2010;78 Suppl 1:S24-34. doi: 10.1002/cyto.b.20543.
5
Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL).根据克隆性 B 细胞在单克隆 B 细胞淋巴细胞增多症(MBL)中的绝对数量,生物学和临床结局不同。
Cytometry B Clin Cytom. 2010;78 Suppl 1(Suppl 1):S19-23. doi: 10.1002/cyto.b.20533.
6
Prevalence of monoclonal B-cell lymphocytosis: a systematic review.单克隆 B 细胞淋巴细胞增多症的患病率:系统评价。
Cytometry B Clin Cytom. 2010;78 Suppl 1(Suppl 1):S10-8. doi: 10.1002/cyto.b.20538.
7
Brief report: natural history of individuals with clinically recognized monoclonal B-cell lymphocytosis compared with patients with Rai 0 chronic lymphocytic leukemia.简短报告:与 Rai 0 期慢性淋巴细胞白血病患者相比,临床诊断为单克隆 B 细胞淋巴细胞增多症个体的自然病程。
J Clin Oncol. 2009 Aug 20;27(24):3959-63. doi: 10.1200/JCO.2008.21.2704. Epub 2009 Jul 20.
8
The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors.临床单克隆B细胞淋巴细胞增多症的预后与Rai 0期慢性淋巴细胞白血病的预后不同,且可由生物学危险因素概括。
Br J Haematol. 2009 Jun;146(1):64-75. doi: 10.1111/j.1365-2141.2009.07711.x. Epub 2009 May 5.
9
Increased frequency (12%) of circulating chronic lymphocytic leukemia-like B-cell clones in healthy subjects using a highly sensitive multicolor flow cytometry approach.采用高灵敏度多色流式细胞术方法,健康受试者中循环慢性淋巴细胞白血病样B细胞克隆的频率增加(12%)。
Blood. 2009 Jul 2;114(1):33-7. doi: 10.1182/blood-2009-01-197368. Epub 2009 May 6.
10
B-cell clones as early markers for chronic lymphocytic leukemia.B细胞克隆作为慢性淋巴细胞白血病的早期标志物。
N Engl J Med. 2009 Feb 12;360(7):659-67. doi: 10.1056/NEJMoa0806122.