Biomaterials, Biomechanics and Tissue Engineering Group, Dpt. Materials Science and Metallurgy, Universitat Politècnica de Catalunya (UPC), Eduard Maristany 10-14, 08019 Barcelona, Spain; Barcelona Research Center in Multiscale Science and Engineering, UPC, Barcelona, Spain; Materials in Medicine Group, Division of Applied Materials Science, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden.
Division of Microsystem Technology, Uppsala University, Department of Engineering Sciences, Uppsala University, Box 534, 751 21 Uppsala, Sweden.
J Mech Behav Biomed Mater. 2017 Nov;75:495-503. doi: 10.1016/j.jmbbm.2017.08.017. Epub 2017 Aug 16.
Calcium phosphate cements (CPCs) are extensively used as synthetic bone grafts, but their poor toughness limits their use to non-load-bearing applications. Reinforcement through introduction of fibers and yarns has been evaluated in various studies but always resulted in a decrease in elastic modulus or bending strength when compared to the CPC matrix. The aim of the present work was to improve the interfacial adhesion between fibers and matrix to obtain tougher biocompatible fiber-reinforced calcium phosphate cements (FRCPCs). This was done by adding a polymer solution to the matrix, with chemical affinity to the reinforcing chitosan fibers, namely trimethyl chitosan (TMC). The improved wettability and chemical affinity of the chitosan fibers with the TMC in the liquid phase led to an enhancement of the interfacial adhesion. This resulted in an increase of the work of fracture (several hundred-fold increase), while the elastic modulus and bending strength were maintained similar to the materials without additives. Additionally the TMC-modified CPCs showed suitable biocompatibility with an osteoblastic cell line.
磷酸钙骨水泥（CPCs）被广泛用作合成骨移植物，但由于其韧性差，限制了其在非承重应用中的使用。在各种研究中，已经评估了通过引入纤维和纱线进行增强，但与 CPC 基体相比，弹性模量或弯曲强度总是会降低。本工作的目的是通过添加聚合物溶液来改善纤维与基体之间的界面粘附性，以获得韧性更好的生物相容性纤维增强磷酸钙骨水泥（FRCPCs）。该聚合物溶液与增强用壳聚糖纤维（即三甲基壳聚糖（TMC））具有化学亲和力，从而实现了这一点。壳聚糖纤维在液相中与 TMC 的润湿性和化学亲和力的提高导致界面粘附性增强。这导致断裂功增加（增加数百倍），而弹性模量和弯曲强度与没有添加剂的材料相似。此外，TMC 改性 CPCs 显示出与成骨细胞系的良好生物相容性。
