LRIG蛋白表达作为原发性阴道癌可能的预后因素
Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma.
作者信息
Ranhem Cecilia, Lillsunde Larsson Gabriella, Hedman Håkan, Lindquist David, Karlsson Mats G, Hellström Ann-Cathrin, Östensson Ellinor, Sorbe Bengt, Hellman Kristina, Andersson Sonia
机构信息
Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Region Västmanland - Uppsala University, Centre for Clinical Research, Hospital of Västmanland Västerås, Västerås, Sweden.
出版信息
PLoS One. 2017 Aug 25;12(8):e0183816. doi: 10.1371/journal.pone.0183816. eCollection 2017.
BACKGROUND
Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients.
METHODS
We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses.
RESULTS
The majority of PVC patients (72%) had >50% LRIG1- and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival.
CONCLUSION
LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.
背景
原发性阴道癌（PVC）是一种罕见的恶性肿瘤。已确定的预后因素包括肿瘤分期和诊断时的年龄。富含亮氨酸重复序列和免疫球蛋白样结构域（LRIG）-1蛋白起着肿瘤抑制作用，但关于LRIG2和LRIG3的功能了解较少。本研究旨在评估LRIG蛋白的表达，并分析它们与一组PVC患者临床特征及生存情况的可能关联。
方法
我们采用免疫组织化学方法研究了70例连续PVC患者肿瘤样本中LRIG1、LRIG2和LRIG3的表达情况。使用单因素和多因素分析研究LRIG蛋白表达与临床特征及癌症特异性生存之间的关联。
结果
大多数PVC患者（72%）有>50%的LRIG1和LRIG2阳性细胞，而LRIG3阳性细胞无或较少。HPV状态与LRIG1表达显著相关（p = 0.0047）。在单因素和多因素分析中，LRIG1高表达与较好的癌症特异性生存显著相关。LRIG2和LRIG3表达与临床特征或生存无显著相关性。
结论
LRIG1表达可能作为PVC患者的预后标志物，而LRIG2和LRIG3表达的作用仍有待阐明。
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