Avila-Luna Alberto, Gálvez-Rosas Arturo, Alfaro-Rodríguez Alfonso, Reyes-Legorreta Celia, Garza-Montaño Paloma, González-Piña Rigoberto, Bueno-Nava Antonio
División de Neurociencias, Instituto Nacional de Rehabilitación,'Luis Guillermo Ibarra Ibarra', Secretaría de Salud, Calzada México-Xochimilco 289, Arenal de Guadalupe, C.P. 14389, Mexico City, Mexico.
División de Neurociencias, Instituto Nacional de Rehabilitación,'Luis Guillermo Ibarra Ibarra', Secretaría de Salud, Calzada México-Xochimilco 289, Arenal de Guadalupe, C.P. 14389, Mexico City, Mexico.
Behav Brain Res. 2018 Jan 15;336:145-150. doi: 10.1016/j.bbr.2017.08.026. Epub 2017 Aug 31.
The sensorimotor cortex and the striatum are interconnected by the corticostriatal pathway, suggesting that cortical injury alters the striatal function that is associated with skilled movements and motor learning, which are functions that may be modulated by dopamine (DA). In this study, we explored motor coordination and balance in order to investigate whether the activation of D receptors (DRs) modulates functional recovery after cortical injury. The results of the beam-walking test showed motor deficit in the injured group at 24, 48 and 96h post-injury, and the recovery time was observed at 192h after cortical injury. In the sham and injured rats, systemic administration of the DR antagonist SCH-23390 (1mg/kg) alone at 24, 48, 96 and 192h significantly (P<0.01) increased the motor deficit, while administration of the DR agonist SKF-38393 alone (2, 3 and 4mg/kg) at 24, 48, 96 and 192h post-injury did not produce a significant difference; however, the co-administration of SKF-38393 and SCH-23390 prevented the antagonist-induced increase in the motor deficit. The cortical+striatal injury showed significantly increased the motor deficit at 24, 48, 96 and 192h post-injury (P<0.01) but did not show recovery at 192h. In conclusion, the administration of the DR agonist did not accelerate the motor recovery, but the activation of DRs maintained motor coordination, confirming that an intact striatum may be necessary for achieving recovery.
感觉运动皮层和纹状体通过皮质纹状体通路相互连接，这表明皮质损伤会改变与熟练运动和运动学习相关的纹状体功能，而这些功能可能受多巴胺（DA）调节。在本研究中，我们探究了运动协调性和平衡能力，以调查D受体（DR）的激活是否能调节皮质损伤后的功能恢复。光束行走测试结果显示，损伤组在损伤后24、48和96小时存在运动缺陷，且在皮质损伤后192小时观察到恢复。在假手术组和损伤大鼠中，在24、48、96和192小时单独全身给予DR拮抗剂SCH-23390（1mg/kg）显著（P<0.01）增加了运动缺陷，而在损伤后24、48、96和192小时单独给予DR激动剂SKF-38393（2、3和4mg/kg）未产生显著差异；然而，SKF-38393和SCH-23390联合给药可防止拮抗剂诱导的运动缺陷增加。皮质+纹状体损伤在损伤后24、48、96和192小时显著增加了运动缺陷（P<0.01），但在192小时未显示恢复。总之，给予DR激动剂并未加速运动恢复，但DR的激活维持了运动协调性，证实完整的纹状体可能是实现恢复所必需的。
