Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea.
Pharmacol Ther. 2018 Feb;182:56-69. doi: 10.1016/j.pharmthera.2017.08.010. Epub 2017 Aug 24.
Age-related neurological disorders (ANDs), including neurodegenerative diseases, are multifactorial disorders with a risk that increases with aging. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Recently, efforts have been made to overcome ANDs because of the increase in age-dependent prevalence. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms. The structure-activity relationships of ginger phytochemicals show that ginger can be used to treat ANDs by targeting different ligand sites. This review shows that ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone, are effective for ameliorating the neurological symptoms and pathological conditions of ANDs through by modulating cell death or cell survival signaling molecules. From this review, we conclude that the active ingredients in ginger have therapeutic potential in ANDs.
年龄相关性神经紊乱（ANDs），包括神经退行性疾病，是一种多因素疾病，其风险随着年龄的增长而增加。ANDs 通常以中枢神经系统的常见神经病理学状况为特征，如氧化应激、神经炎症和蛋白质错误折叠。最近，由于与年龄相关的患病率增加，人们努力克服 ANDs。生姜，是姜科植物姜的根茎，是一种受欢迎的食品香料，在传统医学中用于治疗各种疾病症状已有悠久的历史。生姜植物化学物质的结构-活性关系表明，生姜可以通过靶向不同的配体结合位点来治疗 ANDs。这篇综述表明，生姜及其成分，如 6-姜酚、6-姜烯酚、6-姜酮、姜酮和去氢姜酮，通过调节细胞死亡或细胞存活信号分子，可有效改善 ANDs 的神经症状和病理状况。从这篇综述中，我们得出结论，生姜中的活性成分在 ANDs 中具有治疗潜力。
