Field Seth J
From the Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093.
J Biol Chem. 2017 Aug 25;292(34):14308-14309. doi: 10.1074/jbc.H117.791400.
Phosphatidylserine (PtdSer) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P) have been implicated in the maintenance of caveolae, but direct evidence that these lipids are required for normal caveolar structure and dynamics in living cells has been lacking. A new study by Fairn and colleagues uses sophisticated tools to perturb specific lipids in living cells to assess the consequences for caveolae. This study demonstrates disparate roles for these lipids in the stability and mobility of caveolae and points the way for future work to understand how these lipids contribute to the biology of caveolae.
磷脂酰丝氨酸（PtdSer）和磷脂酰肌醇4,5-二磷酸（PtdIns(4,5)P）与小窝的维持有关，但一直缺乏直接证据表明这些脂质是活细胞正常小窝结构和动态所必需的。Fairn及其同事的一项新研究使用了精密工具来干扰活细胞中的特定脂质，以评估对小窝的影响。这项研究证明了这些脂质在小窝稳定性和流动性方面的不同作用，并为未来理解这些脂质如何影响小窝生物学的研究指明了方向。
