Snene Alì, Sirignano Carmina, Rigano Daniela, Formisano Carmen, El Mokni Ridha, Ercolano Giuseppe, Dhaouadi Hatem, Ianaro Angela, Hammami Saoussen, Taglialatela-Scafati Orazio
Research Unit Applied Chemistry and Environment 13ES63, Monastir University, Faculty of Sciences of Monastir, 5000 Monastir, Tunisia.
Department of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy.
Phytochemistry. 2017 Nov;143:194-198. doi: 10.1016/j.phytochem.2017.08.010. Epub 2017 Aug 23.
Chemical analysis of the dichloromethane fraction obtained from aerial parts of the Northern African endemic plant Daucus virgatus led to the isolation of three previously undescribed sesquiterpenoids, namely the daucane vaginatin B, a eudesmane and the elemane elemavirgolide, along with five known metabolites. The structures of these compounds were determined by a detailed MS and NMR analysis and they were evaluated for antiproliferative activity against three human cell lines, A375 (melanoma), MCF-7 (breast adenocarcinoma), and HACAT (keratinocyte). The phytoalexin 6-methoxymellein revealed a previously unreported antiproliferative activity, while the eudesmane and the elemane derivatives exhibited a selective activity (SI = 11.1 and 3.3, respectively) against melanoma tumor cell lines.
对从北非特有植物细叶胡萝卜的地上部分获得的二氯甲烷馏分进行化学分析，分离出三种此前未描述的倍半萜类化合物，即胡萝卜烷阴道菌素B、一种桉叶烷和榄香烯榄香烯内酯，以及五种已知代谢物。通过详细的质谱和核磁共振分析确定了这些化合物的结构，并对它们针对三种人类细胞系A375（黑色素瘤）、MCF-7（乳腺腺癌）和HACAT（角质形成细胞）的抗增殖活性进行了评估。植物抗毒素6-甲氧基水杨梅素显示出此前未报道的抗增殖活性，而桉叶烷和榄香烯衍生物对黑色素瘤肿瘤细胞系表现出选择性活性（选择性指数分别为11.1和3.3）。
