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从龙葵中分离得到的具有细胞毒性的新桉烷型倍半萜。

New eudesmane-type sesquiterpenoid from Solanum lyratum with cytotoxic activity.

机构信息

a School of Pharmaceutical Science, Yantai University , Yantai 264005 , P.R. China.

出版信息

Nat Prod Res. 2014;28(9):641-5. doi: 10.1080/14786419.2014.891199. Epub 2014 Mar 21.

Abstract

In our continuing effort to discover more new cytotoxic sesquiterpenoids from Solanum lyratum, one new eudesmane-type sesquiterpenoid (1, 3-keto-eudesm-9β,11-diol, named lyratol G), together with one known eudesmane-type sesquiterpenoid (2, 1β-hydroxy-1,2-dihydro-α-santonin), was obtained. The structure of the new sesquiterpenoid was elucidated on the basis of integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D NMR ((1)H-(1)H COSY, HMQC, HMBC and ROESY). In vitro, two sesquiterpenoids were found to exhibit significant cytotoxicity against three cancer cell lines (P-388, HONE-1 and HT-29), and gave IC50 values in the range of 3.1-6.9 μM.

摘要

为了从龙葵中发现更多新型细胞毒素倍半萜,我们获得了一个新的艾烷型倍半萜(1,3-酮基艾里莫烷-9β,11-二醇,命名为龙葵醇 G)和一个已知的艾烷型倍半萜(2,1β-羟基-1,2-二氢-α-蛇床子素)。新型倍半萜的结构基于综合光谱技术(主要是高分辨率快速原子轰击质谱、1D 和 2D NMR ((1)H-(1)H COSY、HMQC、HMBC 和 ROESY)确定。体外实验发现,两种倍半萜对三种癌细胞系(P-388、HONE-1 和 HT-29)表现出显著的细胞毒性,IC50 值在 3.1-6.9 μM 范围内。

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