Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Department of Inorganic Chemistry, Faculty of Pharmacy, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland.
Molecules. 2021 Feb 4;26(4):816. doi: 10.3390/molecules26040816.
Melanoma is a serious form of skin cancer that begins in cells known as melanocytes. While it is less common than the other forms of skin cancer, melanoma is more dangerous because of its ability to spread to other organs more rapidly if it is not treated at an early stage. The number of people diagnosed with melanoma has increased over the last few decades. The most widely used treatments include surgery, chemotherapy, and radiation therapy. The search for new drugs to treat various cancers is one of the most important challenges of modern scientific research. Some isoquinoline alkaloids found in different plant species have strong cytotoxic effects on various cancer cells. We tested the effect of isoquinoline alkaloids and extracts obtained from various parts of collected in various vegetation seasons on human melanoma cancer cells and our data indicated that investigated extract induced significant reduction in cell viability of Human malignant melanoma cells (A375), human Caucasian malignant melanoma cell line (G361), and human malignant melanoma cell line (SKMEL3 cancer cell lines in a dose- and time-dependent manner. Differences in cytotoxic activity were observed for extracts obtained from various parts of . Significant differences were also obtained in the alkaloids content and cytotoxic activity of the extracts depending on the season of collection of plant material. Our investigations exhibit that these plant extracts can be recommended for further in vivo experiments in order to confirm the possibility of their use in the treatment of human melanomas.
黑色素瘤是一种严重的皮肤癌，起源于一种叫做黑色素细胞的细胞。虽然它比其他类型的皮肤癌少见，但由于其在早期阶段未得到治疗时更容易迅速扩散到其他器官，因此更为危险。在过去几十年中，被诊断出患有黑色素瘤的人数有所增加。最广泛使用的治疗方法包括手术、化疗和放射治疗。寻找新的药物来治疗各种癌症是现代科学研究的最重要挑战之一。在不同植物物种中发现的一些异喹啉生物碱对各种癌细胞具有很强的细胞毒性作用。我们测试了异喹啉生物碱和从不同植被季节采集的不同部位获得的提取物对人黑色素瘤癌细胞的影响，我们的数据表明，所研究的提取物以剂量和时间依赖的方式诱导人恶性黑色素瘤细胞（A375）、人白种恶性黑色素瘤细胞系（G361）和人恶性黑色素瘤细胞系（SKMEL3）的细胞活力显著降低。从不同部位获得的提取物的细胞毒性活性存在差异。提取物的生物碱含量和细胞毒性活性也因植物材料采集季节的不同而有显著差异。我们的研究表明，这些植物提取物可以推荐用于进一步的体内实验，以确认它们在治疗人类黑色素瘤中的可能性。
