Lara-Valderrábano Leonardo, Galván Emilio J, Rocha Luisa
Pharmacobiology Department, Center of Research and Advanced Studies, México City, Mexico.
Pharmacobiology Department, Center of Research and Advanced Studies, México City, Mexico.
Epilepsy Res. 2017 Oct;136:126-129. doi: 10.1016/j.eplepsyres.2017.08.006. Epub 2017 Aug 19.
Epilepsy is a highly prevalent neurological disorder. Additionally, a percentage of patients do not respond to conventional antiepileptic drugs. Therefore, drugs for epilepsy control are still being developed. In the present study, the effect of propylparaben (PPB) in the epileptiform activity induced by 4-aminopyridine in hippocampal CA1 pyramidal neurons was evaluated using individual recordings in current-clamp mode. Results indicated that PPB suppressed the epileptiform activity in registered neurons. This effect disappeared when PPB was removed from the solution of incubation. In contrast, phenytoin only reduced the firing frequency without abolishing epileptiform activity. Our results indicate that PPB exerts an antiepileptic effect on CA1 pyramidal neurons in vitro. Therefore, PPB may represent an effective antiepileptic compound.
癫痫是一种高度流行的神经系统疾病。此外，有一定比例的患者对传统抗癫痫药物没有反应。因此，仍在研发用于控制癫痫的药物。在本研究中，使用电流钳模式下的单个记录评估了对羟基苯甲酸丙酯（PPB）对海马CA1锥体神经元中由4-氨基吡啶诱导的癫痫样活动的影响。结果表明，PPB抑制了所记录神经元中的癫痫样活动。当从孵育溶液中去除PPB时，这种作用消失。相比之下，苯妥英仅降低了放电频率，而没有消除癫痫样活动。我们的结果表明，PPB在体外对CA1锥体神经元具有抗癫痫作用。因此，PPB可能是一种有效的抗癫痫化合物。
