Ahmad Basel, Turkmani Khaled, Marwa Mohamad Essam, Ahmad Tareq, Baghdadi Ramez, Aboudamaah Shaimaa, Alkhatib Khetam, Ahmad Mohamad
Faculty of Medicine, Damascus University, Damascus, Syria. Email:
Asian Pac J Cancer Prev. 2017 Aug 27;18(8):2109-2113. doi: 10.22034/APJCP.2017.18.8.2109.
Background: Liver resection is the only viable therapeutic treatment option for several neoplastic entities of the liver. Although, the number of resectable patients is increasing in Syria, liver failure is still a major complication affecting mortality and morbidity rates. Methods: Between 2009 and 2016, 104 patients undergoing liver resection in Damascus University Faculty of Medicine were retrospectively analyzed. Liver function tests were conducted before surgery (ps) and in the perioperative period (po) and comparisons were performed with division into anatomic VS non-anatomic or malignant VS non-malignant groups. Results: Liver synthetic, excretory and detoxifying functions deteriorated after liver resection (INR ps ‘presurgery’=1.129 po ‘perioperative’=1.426 P<0.001, TP ps=7.426 po=5.581 P<0.001, ALB ps=4.204 po=3.242 P<0.001, T-Bill ps=0.061 po=0.136 P<0.001) and liver cell necrosis increased after resection (ALT ps=27.597 po=200.221 P<0.001, AST ps=33.395 po=190.553 P<0.001). There was no significant difference in liver functions when we compared anatomic VS non-anatomic groups or malignant VS non-malignant groups, but liver cell necrosis was higher with malignancies (ALT malignant group=236.475 non-malignant group=89.5 P=0.002, AST malignant group=222.644 non-malignant group=101.125 P=0.001). Conclusion: Although liver resection affects liver function significantly, no differences in outcomes were found between anatomic VS non anatomic or malignant VS non-malignant groups.
肝切除术是治疗多种肝脏肿瘤实体的唯一可行治疗选择。尽管叙利亚可切除患者的数量在增加，但肝衰竭仍是影响死亡率和发病率的主要并发症。方法：对2009年至2016年在大马士革大学医学院接受肝切除术的104例患者进行回顾性分析。在手术前（ps）和围手术期（po）进行肝功能检查，并将患者分为解剖学组与非解剖学组或恶性组与非恶性组进行比较。结果：肝切除术后肝脏的合成、排泄和解毒功能恶化（国际标准化比值ps“术前”=1.129，po“围手术期”=1.426，P<0.001；总蛋白ps=7.426，po=5.581，P<0.001；白蛋白ps=4.204，po=3.242，P<0.001；总胆红素ps=0.061，po=0.136，P<0.001），切除术后肝细胞坏死增加（谷丙转氨酶ps=27.597，po=200.221，P<0.001；谷草转氨酶ps=33.395，po=190.553，P<0.001）。当我们比较解剖学组与非解剖学组或恶性组与非恶性组时，肝功能没有显著差异，但恶性肿瘤患者的肝细胞坏死更高（谷丙转氨酶恶性组=236.475，非恶性组=89.5，P=0.002；谷草转氨酶恶性组=222.644，非恶性组=101.125，P=0.001）。结论：尽管肝切除术对肝功能有显著影响，但在解剖学组与非解剖学组或恶性组与非恶性组之间未发现预后差异。
