Hamlaoui Mohamed Larbi, Ayachi Ammar, Dekaken Aoulia, Gouri Adel
Laboratoire de microbiologie Immunologie, Institut des Sciences Vétérinaires et Agronomiques, Département Vétérinaire, Université de Batna, Algeria.
Department of Internal Medicine, Public Hospital El Okbi, Guelma, Algeria.
Diabetes Metab Syndr. 2018 Jan-Mar;12(1):1-4. doi: 10.1016/j.dsx.2017.08.001. Epub 2017 Aug 10.
The aim of this study is to evaluate the prevalence of the metabolic syndrome and its compounds in subjects with different thyroid status.
A prospective cross-sectional study was conducted in the internal medicine department at El Okbi Hospital of Guelma (East of Algeria) from January 2014 to September 2015. Eighty six patients attending the specialist consultation for suspected thyroid disorders were included in the study. Gender; blood pressure; body mass index; and serum levels of fasting glucose, total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol, and triglyceride were compared between subjects with hypothyroidism, hyperthyroidism and euthyroidism.
Thyroid dysfunction was found in 59.3% (n=42) patients, hypothyroidism (45.3%) was the major thyroid dysfunction followed by hyperthyroidism (14.0%). Overall, the prevalence of metabolic syndrome was 48.8% (n=42). Subjects with hypothyroidism had significantly higher level of BMI, WC, TC, LDL-C, and higher prevalence of abdominal obesity (84.6%, p<0.01) and hypertension (51.2%, p<0.05). The hyperthyroid group had significantly lower level of TC, LDL-C and HDL-C but a higher level of SBP and UA. Furthermore, abdominal obesity, hypertension and low HDL-C level were the most common metabolic syndrome compounds found in the hyperthyroid group compared to the euthyroid group. We found a positive association between TSH level and the prevalence of the metabolic syndrome.
本研究旨在评估不同甲状腺状态受试者中代谢综合征及其组分的患病率。
2014年1月至2015年9月在阿尔及利亚东部盖勒马省埃尔奥克比医院内科进行了一项前瞻性横断面研究。86例因疑似甲状腺疾病前来专科门诊就诊的患者纳入本研究。比较了甲状腺功能减退、甲状腺功能亢进和甲状腺功能正常的受试者之间的性别、血压、体重指数以及空腹血糖、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇和甘油三酯的血清水平。
59.3%（n = 42）的患者存在甲状腺功能障碍，其中甲状腺功能减退（45.3%）是主要的甲状腺功能障碍类型，其次是甲状腺功能亢进（14.0%）。总体而言，代谢综合征的患病率为48.8%（n = 42）。甲状腺功能减退的受试者BMI、腰围、TC、低密度脂蛋白胆固醇水平显著更高，腹部肥胖（84.6%，p < 0.01）和高血压（51.2%，p < 0.05）的患病率更高。甲状腺功能亢进组的TC、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平显著更低，但收缩压和尿酸水平更高。此外，与甲状腺功能正常组相比，甲状腺功能亢进组中腹部肥胖、高血压和低高密度脂蛋白胆固醇水平是最常见的代谢综合征组分。我们发现促甲状腺激素水平与代谢综合征的患病率之间存在正相关。
