Abdel-Gayoum Abdelgayoum A
Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, University of Hail, PO Box 2440, Hail, Kingdom of Saudi Arabia. E-mail.
Saudi Med J. 2014 Dec;35(12):1469-76.
To investigate changes in serum lipid profile, levels of serum minerals associated with thyroid disorders, and to compare these with the serum lipid and mineral profiles in hypothyroid patients receiving thyroxine therapy.
A cross-sectional study was conducted in King Khaled Hospital, Hail, Saudi Arabia. The patient database was searched for new patients with thyroid dysfunction between January 2011 and June 2012. They were classified into 5 groups: 1) subclinical-hypothyroid (SHY), 2) overt-hypothyroid (OHY), 3) subclinical-hyperthyroid (SHE), 4) overt-hyperthyroid (OHE), 5) patients under thyroxine therapy (EU), and normal controls.
The OHY group showed impaired renal function; whereas, the kidney function of the SHE, OHE, and EU groups was normal. The OHY and OHE groups exhibited elevated serum glucose. The OHY group showed elevated serum cholesterol, triglyceride, and low-density lipoprotein cholesterol, and decreased high-density lipoprotein cholesterol. Serum lipids were reduced in the OHE group, and no different in the EU group compared with controls. The serum calcium and phosphate were reduced in the OHY group, whereas, in the OHE group, the phosphate was increased while magnesium and potassium were reduced.
Hypothyroidism caused impaired renal function, glucose intolerance, hyperlipidemia, and reduction in serum phosphate. Hyperthyroidism caused a reduction in serum lipids, magnesium, and potassium. Thyroxine therapy normalized the deranged lipids and minerals, but not glucose. RESULTS indicate that thyroid function tests should be considered when diagnosing those metabolic disorders.
研究血清脂质谱变化、与甲状腺疾病相关的血清矿物质水平，并将其与接受甲状腺素治疗的甲状腺功能减退患者的血清脂质和矿物质谱进行比较。
在沙特阿拉伯哈伊勒的哈立德国王医院进行了一项横断面研究。在患者数据库中搜索2011年1月至2012年6月期间患有甲状腺功能障碍的新患者。他们被分为5组：1）亚临床甲状腺功能减退（SHY），2）显性甲状腺功能减退（OHY），3）亚临床甲状腺功能亢进（SHE），4）显性甲状腺功能亢进（OHE），5）接受甲状腺素治疗的患者（EU），以及正常对照组。
OHY组肾功能受损；而SHE、OHE和EU组的肾功能正常。OHY和OHE组血清葡萄糖升高。OHY组血清胆固醇、甘油三酯和低密度脂蛋白胆固醇升高，高密度脂蛋白胆固醇降低。OHE组血清脂质降低，EU组与对照组相比无差异。OHY组血清钙和磷降低，而OHE组磷升高，镁和钾降低。
甲状腺功能减退导致肾功能受损、葡萄糖耐量异常、高脂血症和血清磷降低。甲状腺功能亢进导致血清脂质、镁和钾降低。甲状腺素治疗使紊乱的脂质和矿物质恢复正常，但未使葡萄糖恢复正常。结果表明，在诊断这些代谢紊乱时应考虑甲状腺功能检查。
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