Tang Kun, Zhang Qiao, Peng Nian-Chun, Zhang Miao, Xu Shu-Jing, Li Hong, Hu Ying, Xue Chun-Ju, Shi Li-Xin
Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Endocrinology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
J Int Med Res. 2020 Nov;48(11):300060520966878. doi: 10.1177/0300060520966878.
To investigate the relationship between thyroid stimulating hormone (TSH) concentration and the risks of developing metabolic syndrome and its components.
A total of 10,140 residents of the Yunyan district of Guiyang (Guizhou, China) who were ≥40 years old were selected by cluster random sampling between May and August 2011, of whom 5692 were eligible. TSH concentration and indices of metabolic syndrome were documented at baseline and 3 years later. Participants were allocated to a euthyroid (TSH 0.55-4.78 mIU/L) or high TSH concentration (TSH >4.78 mIU/L) group. Patients with overt hypothyroidism or were undergoing treatment for hypothyroidism were excluded.
The crude and adjusted prevalences of metabolic syndrome were 39.9% and 33.9% in the euthyroid group and 44.3% and 37.5% in the high TSH group, respectively. Binary logistic regression analysis revealed a positive correlation between a high TSH concentration at baseline and the cumulative incidence of metabolic syndrome during follow up.
High TSH is associated with a higher risk of developing metabolic syndrome or one of its components; therefore, people with a high TSH concentration should be screened regularly to permit the early identification of metabolic syndrome and followed up thoroughly.
探讨促甲状腺激素（TSH）浓度与代谢综合征及其组分发生风险之间的关系。
2011年5月至8月，采用整群随机抽样法选取贵州省贵阳市云岩区10140名年龄≥40岁的居民，其中5692名符合条件。在基线和3年后记录TSH浓度及代谢综合征指标。参与者被分为甲状腺功能正常（TSH 0.55 - 4.78 mIU/L）或高TSH浓度（TSH > 4.78 mIU/L）组。排除明显甲状腺功能减退或正在接受甲状腺功能减退治疗的患者。
甲状腺功能正常组代谢综合征的粗患病率和校正患病率分别为39.9%和33.9%，高TSH组分别为44.3%和37.5%。二元逻辑回归分析显示，基线时高TSH浓度与随访期间代谢综合征的累积发病率呈正相关。
高TSH与发生代谢综合征或其组分之一的较高风险相关；因此，TSH浓度高的人群应定期筛查，以便早期识别代谢综合征并进行全面随访。
