Han Yutong, Wang Chuyuan, Zhang Lihui, Zhu Jun, Zhu Mei, Li Yongze, Teng Di, Teng Weiping, Shan Zhongyan
Department of Endocrinology and Metabolism, The Institute of Endocrinology, National Health Commission (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, China.
Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China.
Front Endocrinol (Lausanne). 2022 Mar 14;13:853889. doi: 10.3389/fendo.2022.853889. eCollection 2022.
Both dyslipidemia and thyroid dysfunction have a high prevalence rate and are important risk factors for cardiovascular diseases. However, the relationship between blood lipids and thyroid dysfunction is still controversial. This study aims to analyze the blood lipids in people with different thyroid functions.
A total of 80937 adults were included in this population-based cross-sectional TIDE survey, which collected demographic and clinical data on thyroid function, blood lipid levels and other metabolic indicators. After screening, the final analysis included 10,747 participants, who were divided into hypothyroidism (n=311), subclinical hypothyroidism (n=5015), hyperthyroidism (n=203), subclinical hyperthyroidism (n=118) and control (n=5100) groups. The risk of dyslipidemia was analyzed by a logistic regression model and divided into groups of female menopausal.
After full adjustment, significant associations were found between hypothyroidism and hypertriglyceridemia. Subclinical hypothyroidism was associated with a significantly higher risk of hypertriglyceridemia and hyper-low density lipoprotein cholesterolemia. Hyperthyroidism was significantly correlated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia but positively correlated with the risk of low-high density lipoprotein cholesterolemia. There was no significant association between subclinical hyperthyroidism and blood lipids. Hypothyroidism increased the risk of hypertriglyceridemia in both premenopausal and postmenopausal females. Subclinical hypothyroidism was significantly associated with increased hypertriglyceridemia and low-high density lipoprotein cholesterolemia in premenopausal females. Hyperthyroidism was significantly associated with a reduced risk of hypercholesterolemia and hyper-low density lipoprotein cholesterolemia in premenopausal females and an increased risk of low-high density lipoprotein cholesterolemia in postmenopausal female.
Abnormal thyroid function has an important effect on blood lipids and is closely related to female menopause.
血脂异常和甲状腺功能障碍的患病率均较高，且都是心血管疾病的重要危险因素。然而，血脂与甲状腺功能障碍之间的关系仍存在争议。本研究旨在分析不同甲状腺功能人群的血脂情况。
这项基于人群的横断面TIDE调查共纳入80937名成年人，收集了有关甲状腺功能、血脂水平和其他代谢指标的人口统计学和临床数据。经过筛选，最终分析纳入10747名参与者，他们被分为甲状腺功能减退组（n = 311）、亚临床甲状腺功能减退组（n = 5015）、甲状腺功能亢进组（n = 203）、亚临床甲状腺功能亢进组（n = 118）和对照组（n = 5100）。通过逻辑回归模型分析血脂异常风险，并按女性绝经情况分组。
经过全面调整后，发现甲状腺功能减退与高甘油三酯血症之间存在显著关联。亚临床甲状腺功能减退与高甘油三酯血症和高-低密度脂蛋白胆固醇血症的风险显著升高相关。甲状腺功能亢进与高胆固醇血症和高-低密度脂蛋白胆固醇血症的风险降低显著相关，但与低-高密度脂蛋白胆固醇血症的风险呈正相关。亚临床甲状腺功能亢进与血脂之间无显著关联。甲状腺功能减退增加了绝经前和绝经后女性患高甘油三酯血症的风险。亚临床甲状腺功能减退与绝经前女性高甘油三酯血症和低-高密度脂蛋白胆固醇血症增加显著相关。甲状腺功能亢进与绝经前女性高胆固醇血症和高-低密度脂蛋白胆固醇血症风险降低显著相关，与绝经后女性低-高密度脂蛋白胆固醇血症风险增加显著相关。
甲状腺功能异常对血脂有重要影响，且与女性绝经密切相关。
