Department of Anatomy, Histology and Anthropology, Faculty of Medicine, Vilnius University, M.K. Čiurlionio 21, Vilnius LT-03101, Lithuania.
Biomedical Physics Laboratory, National Cancer Institute, P. Baublio 3b, Vilnius LT-08406, Lithuania.
Reprod Toxicol. 2017 Oct;73:222-231. doi: 10.1016/j.reprotox.2017.08.016. Epub 2017 Aug 24.
The increasing use of nanoparticles in consumer products raises the concerns of their safety. This study investigated the biological effects of quantum dots (QD) exposure to rats during pregnancy. CdTe QD were injected on the 13th gestation day. Morphological features of 121 fetuses and histological analysis of placentas were performed on the 20th gestation day. The results showed that QD exhibit dose dependent embryotoxicity: survival rates of fetuses were 97% (5mg/kg dose), 86% (10mg/kg dose) and 43% (20mg/kg dose). QD exposure also resulted in the reduction of fetal body length and mass, disturbed ossification of limbs and caused placental tissue damage. QD exhibit no teratogenic effects at the applied doses. It is hypothesized that embryogenesis was impeded due to the placental damage rather than QD penetration and accumulation in the fetuses. To conclude, mothers should be protected from QD exposure during pregnancy.
纳米粒子在消费品中的应用日益广泛，引起了人们对其安全性的担忧。本研究探讨了量子点（QD）在妊娠期间对大鼠的生物学影响。CdTe QD 在第 13 天的妊娠期内被注射。在第 20 天的妊娠期内，对 121 个胎儿的形态特征和胎盘组织进行了组织学分析。结果表明，QD 表现出剂量依赖性的胚胎毒性：胎儿的存活率为 97%（5mg/kg 剂量）、86%（10mg/kg 剂量）和 43%（20mg/kg 剂量）。QD 暴露还导致胎儿体长和体重减少、四肢骨化紊乱，并导致胎盘组织损伤。在应用的剂量下，QD 没有致畸作用。研究假设胚胎发育受阻是由于胎盘损伤，而不是 QD 在胎儿中的穿透和积累。总之，孕妇在怀孕期间应避免接触 QD。
