Qilu Hospital of Shandong University (Qingdao), Qingdao, China.
Qilu Hospital of Shandong University (Qingdao), Qingdao, China.
Biomed Pharmacother. 2017 Nov;95:199-206. doi: 10.1016/j.biopha.2017.08.048. Epub 2017 Sep 12.
Radiotherapy remains a mainstream treatment for patients with unresectable and locally advanced esophageal squamous cell carcinoma (ESCC). However, intrinsic radioresistance of ESCC tumors has largely compromised the efficacy of radiotherapy. The following study investigates the potential radiosensitizing effect of alpinumisoflavone (AIF) and explores its underlying mechanisms in ESCC. Briefly, our results showed that AIF could significantly increase radiosensitivity of ESCC cells both in vitro and in vivo, by increasing the effect of AIF on irradiation-induced DNA damage, apoptosis and cell cycle arrest. Mechanically, AIF aggravated irradiation-induced ROS generation in ESCC cells, which occurred via suppressing the expression of nuclear transcription factor Nrf2 and Nrf2-driven antioxidant molecule NQO-1 and HO-1. Collectively, we concluded that AIF functions as a potent radiosensitizer in human ESCC.
放射治疗仍然是不可切除和局部晚期食管鳞状细胞癌（ESCC）患者的主流治疗方法。然而，ESCC 肿瘤的内在放射抵抗性在很大程度上降低了放射治疗的疗效。本研究探讨了阿朴双黄酮（AIF）在 ESCC 中的潜在放射增敏作用及其作用机制。简要地说，我们的结果表明，AIF 可以通过增加 AIF 对辐射诱导的 DNA 损伤、细胞凋亡和细胞周期阻滞的作用，在体外和体内显著提高 ESCC 细胞的放射敏感性。机制上，AIF 加重了 ESCC 细胞中辐射诱导的 ROS 生成，这是通过抑制核转录因子 Nrf2 的表达以及 Nrf2 驱动的抗氧化分子 NQO-1 和 HO-1 来实现的。综上所述，我们得出结论，AIF 是人类 ESCC 的一种有效的放射增敏剂。
