Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Fujian, 362000, China.
School of pharmacy, China Pharmaceutical University, Nanjing, 211198, China.
Biomed Pharmacother. 2020 May;125:109767. doi: 10.1016/j.biopha.2019.109767. Epub 2020 Feb 12.
Diabetes mellitus (DM) is a major world health problem and one of the most studied diseases, which are highly prevalent in the whole world, it is frequently associated with severe clinical complications, such as diabetic cardiomyopathy, nephropathy, retinopathy, neuropathy etc. Scientific research is continuously casting about for new monomer molecules from Chinese herbal medicine that could be invoked as candidate drugs for fighting against diabetes and its complications. Resveratrol (RES), a polyphenol phytoalexin, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. It is recently gaining scientific interest for RES in controlling blood sugar and fighting against diabetes and its complications properties in various types of diabetic models. These beneficial effects seem to be due to the multiple actions of RES on cellular functions, which make RES become a promising molecule for the treatment of diabetes and diabetic complications. Here, we review the mechanism of action and potential therapeutic use of RES in prevention and mitigation of these diseases in recent ten years to provide a reference for further research and development of RES.
糖尿病（DM）是一个全球性的健康问题，也是研究最多的疾病之一，在全球范围内广泛流行，常伴有严重的临床并发症，如糖尿病性心肌病、肾病、视网膜病变、神经病变等。科学研究一直在不断寻找来自中草药的新单体分子，这些分子可以作为治疗糖尿病及其并发症的候选药物。白藜芦醇（RES）是一种多酚植物抗毒素，具有多种生化和生理作用，包括抗血小板、雌激素和抗炎特性。最近，RES 控制血糖和防治各种类型糖尿病模型中糖尿病及其并发症的特性引起了科学界的兴趣。这些有益的作用似乎是由于 RES 对细胞功能的多种作用，这使得 RES 成为治疗糖尿病和糖尿病并发症的有前途的分子。在这里，我们综述了 RES 在预防和减轻这些疾病中的作用机制和潜在的治疗用途，为 RES 的进一步研究和开发提供参考。
