青光眼、干细胞与基因治疗：我们目前的进展如何？
Glaucoma, Stem Cells, and Gene Therapy: Where Are We Now?
作者信息
Daliri Karim, Ljubimov Alexander V, Hekmatimoghaddam Seyedhossein
机构信息
Neurogenetic Ward, Comprehensive Child Developmental Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Visiting Scientist at Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.
出版信息
Int J Stem Cells. 2017 Nov 30;10(2):119-128. doi: 10.15283/ijsc17029.
Abstract
Glaucoma is the second most common cause of blindness, affecting 70∼80 million people around the world. The death of retinal ganglion cells (RGCs) is the main cause of blindness related to this disease. Current therapies do not provide enough protection and regeneration of RGCs. A novel opportunity for treatment of glaucoma is application of technologies related to stem cell and gene therapy. In this perspective we will thus focus on emerging approaches to glaucoma treatment including stem cells and gene therapy.
摘要
青光眼是导致失明的第二大常见原因，全球约有7000万至8000万人受其影响。视网膜神经节细胞（RGCs）的死亡是与该疾病相关的失明的主要原因。目前的治疗方法无法为RGCs提供足够的保护和再生。青光眼治疗的一个新机会是应用与干细胞和基因治疗相关的技术。因此，在这篇综述中，我们将重点关注包括干细胞和基因治疗在内的青光眼治疗新方法。
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