Zhang Mengyan, Xin Ruolei, Chang Wenhui
1 AIDS Prevention and Control, Shaanxi Provincial Center for Disease Prevention and Control , Xi'an, China .
2 Institute for AIDS/STD Control and Prevention, Beijing Center for Disease Prevention and Control , Beijing, China .
AIDS Res Hum Retroviruses. 2017 Dec;33(12):1270-1273. doi: 10.1089/AID.2017.0186. Epub 2017 Oct 23.
Recently multiple kinds of unique recombinant forms of HIV-1 CRF01_AE/CRF07_BC were identified in China. In this study, we report another near full-length genome of a novel recombinant form (SN121) between CRF01_AE and CRF07_BC from an HIV-1-infected male through heterosexual behavior in Shaanxi province, China. The analysis of SN121 showed that the genome composed of seven interlaced segments, including three CRF07_BC and four CRF01_AE segments with CRF01_AE as the backbone. Six breakpoints were observed in the pol and env gene regions, which are different from the previously identified CRF01_AE/07_BC recombinant forms in China. This novel emerging recombinant form suggested the complicated genetic diversity and the active local transmission of HIV-1 in Shaanxi province. Further monitoring should be performed to elucidate the possible molecular evolution of this novel recombinant form.
最近在中国发现了多种独特的HIV-1 CRF01_AE/CRF07_BC重组形式。在本研究中，我们报告了来自中国陕西省一名通过异性性行为感染HIV-1的男性的CRF01_AE和CRF07_BC之间一种新型重组形式（SN121）的另一个近全长基因组。对SN121的分析表明，该基因组由七个交错片段组成，包括三个CRF07_BC片段和四个CRF01_AE片段，以CRF01_AE为骨干。在pol和env基因区域观察到六个断点，这与中国先前鉴定的CRF01_AE/07_BC重组形式不同。这种新出现的重组形式表明陕西省HIV-1的遗传多样性复杂且当地传播活跃。应进一步监测以阐明这种新型重组形式可能的分子进化。
