Dong Zhe, Shen Zhiyong, Xiong Runsong, Liang Fuxiong, Liang Shujia, Li Jianjun, Tan Guangjie, Jiang He, Yang Xiaoyi, Li Fan, Liao Lingjie, Shao Yiming, Feng Yi, Zhu Qiuying
1 State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention , Beijing, People's Republic of China .
2 School of Public Health, Peking Union Medical College , Beijing, People's Republic of China .
AIDS Res Hum Retroviruses. 2016 Jul;32(7):689-93. doi: 10.1089/AID.2015.0329. Epub 2016 Mar 23.
In this research, we reported a new second generation recombinant form (GXDY460B) between circulating recombinant form (CRF)01_AE and CRF07_BC in a seroconversion couple who obtained the virus from her husband by heterosexual behavior. The analysis result of the near full-length genomic characterization showed that the genome comprises at least 12 interlaced segments, including six CRF07_BC and six CRF01_AE segments, with CRF07_BC as the main framework. Cocirculation of multiple virus subtypes and multiple infection routes have existed for a long time in Guangxi, but the recombinant strain was rarely reported among heterosexual transmission population because of its lower crowd confounding degree than men who have sex with men and injecting drug user population. It is the first time that the unique recombinant form (URF) between CRF01_AE and CRF07_BC was identified among heterosexual transmission in Guangxi. The emergence of the novel recombinant helps to understand the pattern of the URF virus.
在本研究中，我们报告了在一对血清转化夫妇中发现的一种新型第二代重组形式（GXDY460B），该夫妇通过异性性行为从丈夫那里感染了病毒，其病毒介于流行重组形式（CRF）01_AE和CRF07_BC之间。近乎全长基因组特征的分析结果表明，该基因组至少包含12个交错片段，其中包括6个CRF07_BC片段和6个CRF01_AE片段，以CRF07_BC为主要框架。广西长期存在多种病毒亚型的共同流行和多种感染途径，但由于该重组毒株在异性传播人群中的人群混杂程度低于男男性行为者和注射吸毒人群，因此在异性传播人群中很少有相关报道。这是首次在广西异性传播中鉴定出CRF01_AE和CRF07_BC之间的独特重组形式（URF）。这种新型重组体的出现有助于了解URF病毒的模式。
