West J D, Gosden J R, Angell R R, Hastie N D, Thatcher S S, Glasier A F, Baird D T
Lancet. 1987 Jun 13;1(8546):1345-7. doi: 10.1016/s0140-6736(87)90650-7.
Human male pre-embryos were identified by means of DNA-DNA in-situ hybridisation with a commercially available DNA probe for Y-chromosome DNA. This method could lead to prenatal diagnosis of genetic disorders based on small numbers of cells that are not necessarily in division, such as cells obtained from a pre-embryo during the course of in-vitro fertilisation therapy.
