New York University (NYU) School of Medicine, NYU Langone Medical Center, New York, NY, United States.
NYU Health Sciences Library, NYU Langone Medical Center, New York, NY, United States.
Reprod Toxicol. 2017 Oct;73:175-183. doi: 10.1016/j.reprotox.2017.08.015. Epub 2017 Aug 24.
Hydroxy-4-methoxybenzophenone, also known as benzophenone-3 (BP-3), is a commonly used ultraviolet filter in skincare and as a food additive. Large concentrations of similar phenolic compounds have been detected in urine, amniotic fluid, and placental tissue, thereby raising questions about its impact on reproduction. The objective of this paper was to investigate the reproductive toxicity of BP-3 in humans and animals. In humans, studies showed that high levels of BP-3 exposure could be linked to an increase in male birth weight but a decline in female birth weight and male gestational age. In fish, BP-3 exposure resulted in a decline in egg production, hatching, and testosterone, along with a down-regulation of steroidogenic genes. In rats, a decrease in epididymal sperm density and a prolonged estrous cycle for females was observed. These positive associations may be attributed to an altered estrogen and testosterone balance as a result of endocrine disrupting effects of BP-3. However, the current body of literature is limited by non-uniform exposure and outcome measurements in studies both across and within species and future studies will need to be conducted in a standardized fashion to allow for a more significant contribution to the literature that allows for better comparison across studies.
羟基-4-甲氧基二苯甲酮，也称为二苯甲酮-3（BP-3），是一种常用于护肤品的紫外线滤光剂，也是一种食品添加剂。在尿液、羊水和胎盘组织中检测到大量类似的酚类化合物，这引起了人们对其对生殖影响的关注。本文旨在研究 BP-3 在人类和动物中的生殖毒性。在人类中，研究表明，高水平的 BP-3 暴露可能与男性出生体重增加但女性出生体重和男性胎龄下降有关。在鱼类中，BP-3 暴露导致产卵、孵化和睾酮减少，以及类固醇生成基因的下调。在大鼠中，观察到附睾精子密度降低和雌性动情周期延长。这些正相关可能归因于 BP-3 的内分泌干扰作用导致雌激素和睾酮平衡的改变。然而，目前的文献受到研究中跨物种和同一物种内非统一暴露和结果测量的限制，未来的研究需要以标准化的方式进行，以便为文献做出更重要的贡献，从而允许在研究之间进行更好的比较。
