Um Yoo Hyun, Choi Woo Hee, Jung Won Sang, Park Young Ha, Lee Chang-Uk, Lim Hyun Kook
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Radiology, Division of Nuclear Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Republic of Korea.
Psychiatry Investig. 2017 Jul;14(4):521-524. doi: 10.4306/pi.2017.14.4.521. Epub 2017 Jul 11.
With recent advancement in amyloid imaging, diagnostic application of this new modality has become a great interest among researchers. New ligands, such as 18F- florbetaben, florbetapir and flutemetamol, have been discovered to overcome limitations of preexisting ligand Pittsburgh compound B. We report here a case of a 37-year-old male patient whose initial complaints comprised of gradual cognitive decline, apraxia, disorientation and sleep disturbances. 18F-Florbetaben amyloid imaging of the patient showed diffuse amyloid retention with prominent striatal uptake. This finding supports the clinical utility of amyloid imaging in diagnostic process of early-onset AD. Moreover, striatal dominant uptake pattern demonstrated in this patient include some meaningful clinical implications that warrant special attention among clinicians.
随着淀粉样蛋白成像技术的最新进展，这种新方法的诊断应用已引起研究人员的极大兴趣。已发现新的配体，如18F-氟贝他班、氟代匹哌酸和氟美他莫，以克服先前存在的配体匹兹堡化合物B的局限性。我们在此报告一例37岁男性患者，其最初症状包括逐渐认知衰退、失用症、定向障碍和睡眠障碍。该患者的18F-氟贝他班淀粉样蛋白成像显示弥漫性淀粉样蛋白滞留，并伴有明显的纹状体摄取。这一发现支持了淀粉样蛋白成像在早发性阿尔茨海默病诊断过程中的临床应用价值。此外，该患者显示的纹状体优势摄取模式具有一些有意义的临床意义，值得临床医生特别关注。
