Notch信号通路在造血干细胞调控中的作用
Notch Signaling in the Regulation of Hematopoietic Stem Cell.
作者信息
Lampreia Fabio Pereira, Carmelo Joana Gonçalves, Anjos-Afonso Fernando
机构信息
Haematopoietic Signalling Group, European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Hadyn Ellis Building, Maindy Road, Cardiff, CF24 4HQ UK.
Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, Portugal.
出版信息
Curr Stem Cell Rep. 2017;3(3):202-209. doi: 10.1007/s40778-017-0090-8. Epub 2017 Jul 10.
PURPOSE OF REVIEW
Understanding the signaling pathways that govern hematopoietic stem and progenitor cells (HSPCs) is fundamental to uncover their regulation and how this is skewed in hematological malignancies. Whether Notch is necessary for the regulation of mammalian HSPCs is still unclear. We therefore critically review the current literature on the role of Notch in HSPCs.
RECENT FINDINGS
HSPCs have shown different requirements for Notch signals in vitro and in vivo and at different stages of differentiation. Additionally, bone marrow niche cells activate Notch signaling in HSPCs enhancing their regenerative and self-renewal capacity.
SUMMARY
Despite the controversy, adequate levels of Notch signaling appear necessary to avoid the development of hematological malignancies. Contrary to early studies, recent research suggests that Notch signaling may play a role in homeostatic and regenerative hematopoiesis but further investigation is necessary to understand how it is regulated by the different ligand/receptor pairings and the molecular mechanisms that are triggered.
综述目的
了解调控造血干细胞和祖细胞（HSPCs）的信号通路对于揭示它们的调控机制以及这种调控在血液系统恶性肿瘤中是如何失衡的至关重要。Notch对于哺乳动物HSPCs的调控是否必要仍不清楚。因此，我们对当前关于Notch在HSPCs中作用的文献进行了批判性综述。
最新发现
HSPCs在体外、体内以及不同分化阶段对Notch信号表现出不同的需求。此外，骨髓龛细胞激活HSPCs中的Notch信号，增强其再生和自我更新能力。
总结
尽管存在争议，但适当水平的Notch信号似乎对于避免血液系统恶性肿瘤的发生是必要的。与早期研究相反，最近的研究表明Notch信号可能在稳态和再生造血中发挥作用，但需要进一步研究以了解其如何受不同配体/受体配对调控以及所触发的分子机制。
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