Hayashi Takuji, Fujita Kazutoshi, Nojima Satoshi, Hayashi Yujiro, Nakano Kosuke, Ishizuya Yu, Wang Cong, Yamamoto Yoshiyuki, Kinouchi Toshiro, Matsuzaki Kyosuke, Kawamura Norihiko, Jingushi Kentaro, Kawashima Atsunari, Nagahara Akira, Ujike Takeshi, Uemura Motohide, Imamura Ryoichi, Morii Eiichi, Nonomura Norio
Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Pathology, Osaka University Graduate School of Medicine, Suita, Japan.
Prostate. 2017 Oct;77(14):1383-1388. doi: 10.1002/pros.23398. Epub 2017 Aug 28.
Tumor-infiltrating macrophages, which are thought to be derived from blood monocytes, interact with tumor cells to promote cancer progression. The aim of this study was to assess the association of peripheral blood monocyte count with pathological findings and local tumor-infiltrating macrophages in prostatectomy specimens.
Preoperative peripheral blood monocyte counts were retrospectively assessed for their associations with pathological findings (pathological T stage, Gleason Score, extraprostatic extension, seminal vesicle invasion, and surgical margin) and biochemical recurrence of 248 patients who underwent radical prostatectomy. Local tumor-infiltrating macrophages were also evaluated immunohistochemically for their association with peripheral monocyte counts.
The peripheral monocyte counts of the patients with extraprostatic extension, seminal vesicle invasion, or primary Gleason ≥4 were significantly higher than those of the patients without each of these pathological findings (P < 0.001, P = 0.034, and P = 0.004, respectively). Peripheral monocyte count was a significant predictor of adverse pathology and postoperative biochemical recurrence in localized prostate cancer by multivariate analysis (P = 0.001 and P = 0.041, respectively). Both the density and the count of tumor-infiltrating macrophages correlated significantly with the peripheral blood monocyte count (Spearman rank correlation coefficients were 0.463 and 0.649, respectively, P < 0.001).
Peripheral blood monocyte count reflecting local tumor-infiltrating macrophages was a predictive factor for tumor progression and prognosis in patients with localized prostate cancer. Elucidating the mechanism of the interaction of peripheral monocytes with tumor-infiltrating macrophages is necessary.
肿瘤浸润巨噬细胞被认为起源于血液单核细胞，其与肿瘤细胞相互作用促进癌症进展。本研究旨在评估外周血单核细胞计数与前列腺切除标本的病理结果及局部肿瘤浸润巨噬细胞之间的关联。
回顾性评估248例行根治性前列腺切除术患者的术前外周血单核细胞计数与病理结果（病理T分期、Gleason评分、前列腺外侵犯、精囊侵犯及手术切缘）及生化复发的相关性。还通过免疫组织化学评估局部肿瘤浸润巨噬细胞与外周单核细胞计数的关联。
有前列腺外侵犯、精囊侵犯或原发性Gleason评分≥4的患者外周单核细胞计数显著高于无这些病理结果的患者（分别为P < 0.001、P = 0.034和P = 0.004）。多因素分析显示，外周单核细胞计数是局限性前列腺癌不良病理及术后生化复发的显著预测指标（分别为P = 0.001和P = 0.041）。肿瘤浸润巨噬细胞的密度和计数均与外周血单核细胞计数显著相关（Spearman等级相关系数分别为0.463和0.649，P < 0.001）。
反映局部肿瘤浸润巨噬细胞的外周血单核细胞计数是局限性前列腺癌患者肿瘤进展和预后的预测因素。阐明外周单核细胞与肿瘤浸润巨噬细胞相互作用的机制很有必要。
