Luo Jie, Li Li-Mei, Wang Yue-de, Zhou Kun, Dong Wei, Ye Yan-Qing, Gao Xue-Mei, Du Gang, Yang Hai-Ying, Hu Qiu-Fen, Zhou Min
Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, China.
Zhongguo Zhong Yao Za Zhi. 2016 Jan;41(1):92-95. doi: 10.4268/cjcmm20160118.
A new isocoumarin, along with five known ones,were isolated from the fermentation products of an endophytic fungus Aspergillus versicolorby using various chromatographic techniques.Their structures were elucidated on the basis of extensivespectroscopic analysis, including 1D-and 2D-NMR techniques. Compound 1 was evaluated for cytotoxicity against five human tumor cell lines. The results showed that 1 exhibited weak cytotoxicityagainst NB4, SHSY5Y and MCF7 cells with IC₅₀ values of 6.8, 4.3,8.8 μmol•L⁻¹, respectively.
通过各种色谱技术，从内生真菌杂色曲霉的发酵产物中分离出一种新的异香豆素和五种已知的异香豆素。基于广泛的光谱分析，包括一维和二维核磁共振技术，阐明了它们的结构。对化合物1针对五种人类肿瘤细胞系的细胞毒性进行了评估。结果表明，化合物1对NB4、SHSY5Y和MCF7细胞表现出较弱的细胞毒性，IC₅₀值分别为6.8、4.3、8.8 μmol•L⁻¹。
