海洋来源真菌 Aspergillus sp. 085242 中分离得到的新呋喃并[3,2-h]异色满。

New furo[3,2-h]isochroman from the mangrove endophytic fungus Aspergillus sp. 085242.

机构信息

School of Chemistry, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, South China Normal University, Guangzhou 510006, China.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China.

出版信息

Chin J Nat Med. 2020 Nov;18(11):855-859. doi: 10.1016/S1875-5364(20)60028-0.

DOI:10.1016/S1875-5364(20)60028-0

PMID:33308608

Abstract

Four new compounds, asperisocoumarin G (1), asperisocoumarin H (2), (±)-asperisocoumarin I [(±)-3], along with the known pergillin (4) and penicisochroman L (5) were isolated from a mangrove endophytic fungus Aspergillus sp. 085242 by further chemical investigation. The structures of the new compounds, including their absolute configurations, were established by analysis of HR-ESI-MS and NMR spectroscopic data, and ECD calculation. Asperisocoumarins G-I (1-3) were new isocoumarins belonging to the class of furo[3, 2-h]isocoumarins which are rarely found in natural sources. All of the isolated compounds were evaluated for their α-glucosidase inhibitory effects, and compounds 1 and 4 showed moderate α-glucosidase inhibitory activity, respectively. In an antimicrobial test, the racemate of 3 showed antibacterial activity against Salmonella.

摘要

从红树林内生真菌 Aspergillus sp. 085242 中通过进一步的化学研究，分离得到了 4 种新化合物，分别为asperisocoumarin G (1)、asperisocoumarin H (2)、(±)-asperisocoumarin I [(±)-3]，以及已知化合物 pergillin (4)和 penicisochroman L (5)。通过 HR-ESI-MS 和 NMR 光谱数据分析和 ECD 计算确定了新化合物的结构，包括其绝对构型。 Asperisocoumarins G-I (1-3) 是属于呋喃[3,2-h]异香豆素类的新型异香豆素，在天然产物中很少见。对所有分离得到的化合物进行了α-葡萄糖苷酶抑制活性评价，化合物 1 和 4 分别表现出中等的α-葡萄糖苷酶抑制活性。在抗菌试验中，3 的外消旋体对沙门氏菌具有抗菌活性。